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Chemical Structure| 1219130-25-2 Chemical Structure| 1219130-25-2

Structure of 1219130-25-2

Chemical Structure| 1219130-25-2

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Product Details of [ 1219130-25-2 ]

CAS No. :1219130-25-2
Formula : C10H15N3O3
M.W : 225.24
SMILES Code : NC1=NC(OCC2OC(C)(C)OC2)=CN=C1
MDL No. :MFCD15147079

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Application In Synthesis of [ 1219130-25-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1219130-25-2 ]

[ 1219130-25-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 33332-28-4 ]
  • [ 100-79-8 ]
  • [ 1219130-25-2 ]
YieldReaction ConditionsOperation in experiment
50% To a solution of solketal (48.7 g, 0.369 mol) in 1,4-dioxane (1500 mL) was added NaH (14.8 g, 369 mmol) at room temp and stirred for 2 h. Then 6-chloropyrazin-2-amine (34; 16.0 g, 123 mmol) was added and the mixture was stirred at 120 °C for 12 h. The solvent was removed and ethyl acetate (1000 mL) was added. The mixture was washed with brine (1000 mL x 3), The organic solvent was dried over Na2SO4, concentrated in vacuo and purified by chromatography on silica gel (dichloromethane:methanol=30:l-10:l) to give 6-((2,2-dimethyl-l,3-dioxolan-4- yl)methoxy)pyrazin-2-amine (35; 13.8 g, 61.3 mmol, 50percent) as a yellow solid. MS (ESI) calcd for C10H15N3O3 (m/z) 225.24, found: 226 [M+ H].
 

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