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Chemical Structure| 1216814-90-2 Chemical Structure| 1216814-90-2

Structure of 1216814-90-2

Chemical Structure| 1216814-90-2

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Product Details of [ 1216814-90-2 ]

CAS No. :1216814-90-2
Formula : C17H16ClN3O2
M.W : 329.78
SMILES Code : CN(C1=CC=C(OC)C=C1)C2=C3C=C(OC)C=CC3=NC(Cl)=N2

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Application In Synthesis of [ 1216814-90-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1216814-90-2 ]

[ 1216814-90-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 105763-77-7 ]
  • [ 5961-59-1 ]
  • [ 1216814-90-2 ]
YieldReaction ConditionsOperation in experiment
98% With sodium acetate; In tetrahydrofuran; water; at 60 - 70℃; for 3h; A mixture of <strong>[105763-77-7]2,4-dichloro-6-methoxy-quinazoline</strong> (0.5 g, 2.18 mmol), (4-methoxy-phenyl)-methyl-amine (0.35 g, 2.61 mmol) and sodium acetate (0.21 g, 2.61 mmol) in 8 mL of solvent (1:1 THF:water) was stirred at 60-70 C. for 3 h. The reaction mixture was concentrated and the resulting solid was dissolved in ethyl acetate and filtered through a pad of silica, washing with 40% ethyl acetate/hexane. The filtrate was concentrated under reduced pressure to give 0.7 g of the title compound (98% yield). 1H NMR (DMSO-d6) delta 7.6 (d, 1H), 7.36-7.31 (m, 3H), 7.08-7.05 (dd, 2H), 6.2 (d, 1H), 3.79 (s, 3H), 3.5 (s, 3H), 3.28 (s, 3H); LC-MS (ESI+; 330 ([M+H]+).
 

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