1214386-37-4|Methyl 2-chloro-6-(trifluoromethyl)benzoate| Ambeed

Yield	Reaction Conditions	Operation in experiment
		The mixture of <strong>[2376-00-3]2-chloro-6-(trifluoromethyl)benzoic acid</strong> (i-la) (1.5 g, 6.70 mol) and (COCl)2 (1.1 ml, 13.4 mol) in DCM (20 ml) and DMF (5drops) was stirred at room temperature for 2h.Then MeOH (0.41 ml, 13.4 mol) was added dropwise and the reaction mixture was stirred at room temperature for another 30min.The result solution was diluted with H20 (50 ml) and the aqueous layer was extracted with DCM(50ml><2). The combined organic layers were washed with brine (50 ml x 1), dried over anhydrous Na2S04 and concentrated to get the desired product i-lb as a pale yellow oil. LCMS (ESI) calc'd for C9H6C1F302 [M+H] +: 239, found: 239.
		A mixture of <strong>[2376-00-3]2-chloro-6-(trifluoromethyl)benzoic acid</strong> (i-la) (1.5 g, 6.70 mmol) and (COCl)2 (1.1 ml, 12.8 mmol) in DCM (20 ml) and DMF (5 drops) were stirred at room temperature for 2h. MeOH (0.41 ml, 13.4 mmol) was added dropwise and the reaction mixture was stirred at room temperature for another 30min.The resultant solution was diluted with H20 (50 ml) and the aqueous layer was extracted with DCM (50ml x 2). The combined organic layers were washed with brine (50 ml x 1), dried over anhydrous Na2S04 and concentrated to obtain the title compound i-lb as a pale yellow oil. LCMS (ESI) calc'd for C9H6C1F302 [M+H] +: 239, found: 239.

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Methyl 2-chloro-6-(trifluoromethyl)benzoate

CAS No.: 1214386-37-4

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[ 1214386-37-4 ] Synthesis Path-Downstream 1~1

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