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Chemical Structure| 1211535-74-8 Chemical Structure| 1211535-74-8

Structure of 1211535-74-8

Chemical Structure| 1211535-74-8

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Product Details of [ 1211535-74-8 ]

CAS No. :1211535-74-8
Formula : C8H8FNO
M.W : 153.15
SMILES Code : CC(C1=NC=C(F)C=C1C)=O

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Application In Synthesis of [ 1211535-74-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1211535-74-8 ]

[ 1211535-74-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 111-34-2 ]
  • [ 38186-84-4 ]
  • [ 1211535-74-8 ]
YieldReaction ConditionsOperation in experiment
With sodium hydrogencarbonate;palladium diacetate; 1,3-bis-(diphenylphosphino)propane; In methanol; at 20 - 130℃; for 20h; A. 7-(5 -Fluoro-3 -methylpyridin-2-yl)-N-(5 -(trifluoromethyl)pyrimidin-2-yl)- 1 , 8 -naphthyridin-4- amine (compound 1)1. 2-Acetyl-5-fluoro-3-methylpyridine Dissolve 2-chloro-5 -fluoro-3 -methylpyridine (1.45 g, 0.01 moles) in MeOH (30 mL) at room temperature. Add butylvinylether (3.0 mL) and NaHCO3 (3.0 g) to the reaction mixture and degas with nitrogen for 5 minutes. Add catalyst Pd(OAc)2 (120 mg) and 1,3- bis(diphenylphosphino)propane (360 mg) to the mixture and then heat at 13O0C in a pressure vessel with stirring for 20 hours. Cool the reaction mixture to room temperature and remove the insoluble EPO <DP n="50"/>material by filtration. Wash the solid with MeOH (25 mL) and then add 5.0 mL of 6.0 N aqueous HCl to the filtrate. Stir the mixture at room temperature for 20 hours. Concentrate the reaction mixture under vacuum, dilute it with EtOAc (100 mL), wash the organic layer with aq. Na2CO3 (2 x 50 mL) and dry (MgSO4). Filter the dried extract and concentrate under vacuum to afford crude product as pink oil. Purify the crude product by column chromatography to afford pure product as colorless oil.
 

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