Structure of Ribociclib
CAS No.: 1211441-98-3
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Ribociclib (LEE01) demonstrates high specificity as a CDK4/6 inhibitor, displaying IC50 values of 10 nM and 39 nM, respectively, while being over 1,000-fold less potent against the cyclin B/CDK1 complex.
Synonyms: LEE011
4.5
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Batch number can be found on the product's label following the word 'Batch'.
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Batch number can be found on the product's label following the word 'Batch'.
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Batch number can be found on the product's label following the word 'Batch'.
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Adam M. Weiss ; Marcos A. Lopez II ; Matthew G. Rosenberger ; Jeremiah Y. Kim ; Jingjing Shen ; Qing Chen , et al.
Abstract: Several FDA-approved adjuvants signal through the NLRP3 inflammasome and IL-1β release. Identifying small molecules that induce IL-1β release could allow targeted delivery and structure−function optimization, thereby improving safety and efficacy of next-generation adjuvants. In this work, we leverage our existing high throughput data set to identify small molecules that induce IL-1β release. We find that ribociclib induces IL-1β release when coadministered with a TLR4 agonist in an NLRP3- and caspase-dependent fashion. Ribociclib was formulated with a TLR4 agonist into liposomes, which were used as an adjuvant in an ovalbumin prophylactic vaccine model. The liposomes induced antigen-specific immunity in an IL-1 receptor-dependent fashion. Furthermore, the liposomes were coadministered with a tumor antigen and used in a therapeutic cancer vaccine, where they facilitated rejection of E.G7-OVA tumors. While further chemical optimization of the ribociclib scaffold is needed, this study provides proof-of-concept for its use as an IL-1 producing adjuvant in various immunotherapeutic contexts.
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CAS No. : | 1211441-98-3 |
Formula : | C23H30N8O |
M.W : | 434.54 |
SMILES Code : | O=C(C1=CC2=CN=C(NC3=NC=C(N4CCNCC4)C=C3)N=C2N1C5CCCC5)N(C)C |
Synonyms : |
LEE011
|
MDL No. : | MFCD27976795 |
InChI Key : | RHXHGRAEPCAFML-UHFFFAOYSA-N |
Pubchem ID : | 44631912 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302 |
Precautionary Statements: | P280-P305+P351+P338 |
Target |
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Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT02431481 | Normal Renal Function|Impaired... More >> Renal Function Less << | PHASE1 | COMPLETED | 2018-05-11 | DaVita Clinical Research, Minn... More >>eapolis, Minnesota, 55404, United States|Novartis Investigative Site, Sofia, 1612, Bulgaria|Novartis Investigative Site, Praha 4, Czech Republic, 140 59, Czechia|Novartis Investigative Site, Berlin, 14050, Germany Less << |
NCT02388620 | Normal Hepatic Function|Impair... More >>ed Hepatic Function Less << | PHASE1 | COMPLETED | 2017-01-09 | Anaheim Clinical Trials, Anahe... More >>im, California, 92801, United States|University of Miami, Coral Gables, Florida, 33124, United States|Orlando Clinical Research Center, Orlando, Florida, 32809, United States Less << |
NCT05038631 | Breast Cancer | AVAILABLE | - | - | |
NCT03956654 | Breast Cancer | COMPLETED | 2024-06-30 | UZ Gasthuisberg Leuven, Leuven... More >>, B-3000, Belgium Less << | |
NCT04657679 | Breast Cancer | PHASE4 | TERMINATED | 2023-10-30 | MedStar Georgetown University ... More >>Hospital, Washington, District of Columbia, 20007, United States|Medstar Washington Hospital Center, Washington, District of Columbia, 20010, United States|Tufts Medical Center, Boston, Massachusetts, 02111, United States Less << |
NCT03096912 | Liposarcomas, Dedifferentiated... More >>|Liposarcoma - Well Differentiated|Liposarcoma; Mixed Type|Soft-Tissue Sarcoma Less << | PHASE2 | UNKNOWN | 2025-04-20 | Assaf Harofeh Medical Center, ... More >>Be'er Ya'aqov, 70300, Israel Less << |
NCT06587789 | Breast Cancer | RECRUITING | 2027-01-01 | Second Affiliated Hospital of ... More >>Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China Less << | |
NCT05452213 | Breast Cancer|Breast Neoplasms... More >>|Breast Neoplasm Female|Breast Cancer Female|HER2-negative Breast Cancer|Hormone Receptor-positive Breast Cancer|Advanced Breast Cancer Less << | PHASE4 | RECRUITING | 2025-10-26 | Department of Gynecology and O... More >>bstetrics, Erlangen University Hospital, Erlangen, Bavaria, 91054, Germany|Department of Gynecology and Obstetrics, University Medicine Mainz, Mainz, Hesse, 55131, Germany|Department for Gynecology and Obstetrics, Marienhospital Bottrop gGmbH, Bottrop, North Rhine-Westphalia, 46236, Germany|Klinikum St Marien Amberg, Amberg, 92224, Germany|Onkologie Aschaffenburg, H?mato-Onkologische Schwerpunktpraxis am Klinikum Aschaffenburg, Aschaffenburg, 63739, Germany|Klinik für H?matologie und Onkologie, Uniklinik Augsburg, Augsburg, 86156, Germany|University Hospital Augsburg, Augsburg, 86156, Germany|Frauenklinik des Klinikums Bamberg, Bamberg, 96049, Germany|MediOnko GbR, Berlin, 10367, Germany|HELIOS Klinikum Berlin-Buch, Berlin, 13125, Germany|Zentrum für ambulante H?matologie und Onkologie (ZAHO) an der Robert-Janker-Klinik, Bonn, 53129, Germany|Klinik für Gyn?kologie, Gyn?koonkologie und Senologie Klinikum Bremen-Mitte, Bremen, 28205, Germany|Klinikum Chemnitz gGmbH, Klinik für Frauenheilkunde und Geburtshilfe, Chemnitz, 09116, Germany|Kliniken Der Stadt K?ln gGmbH, Cologne, 51067, Germany|Carl-Thiem-Klinikum Cottbus, Cottbus, 03048, Germany|Staedtisches Klinikum Dessau, Gynecology and Obstetrics, Dessau, 06847, Germany|Universit?ts-Frauenklinik Carl Gustav Carus Universit?t Dresden, Dresden, 01307, Germany|Universitaetsklinikum Duesseldorf A?R, Duesseldorf, 40225, Germany|Universitaetsklinikum Essen A?R, Gynecology and Obstetrics, Essen, 45147, Germany|Klinikum Esslingen GmbH, Esslingen, 73730, Germany|Agaplesion Frankfurter Diakonie Kliniken gGmbH, Gynecology and Obstetrics, Frankfurt Am Main, 60431, Germany|Universit?ts-Frauenklinik Frankfurt, Frankfurt am Main, 60596, Germany|Universit?ts-Frauenklinik Freiburg, Freiburg, 79106, Germany|Medizinisches Versorgungszentrum Onkologie Georgsmarienhütte und Bramsche, Georgsmarienhütte, 49124, Germany|Universit?ts-Frauenklinik Hamburg-Eppendorf, Hamburg, 20246, Germany|Mammazentrum Hamburg am Krankenhaus Jerusalem, Hamburg, 20357, Germany|Nationales Centrum für Tumorerkrankungen, Universit?tsklinikum Heidelberg Abteilung für Gyn?kologie und Geburtshilfe, Heidelberg, 69120, Germany|Frauenklinik, SLK-Kliniken Heilbronn GmbH, Heilbronn, 74078, Germany|Staedtisches Klinikum Karlsruhe gGmbH, Gynecology and Obstetrics, Karlsruhe, 76133, Germany|University Medical Centre Schleswig-Holstein, Gynecology and Obstetrics, Kiel, 24105, Germany|ZAGO-Zentrum für ambulante gyn?kologische Onkologie, Krefeld, 47805, Germany|Klinikum Kulmbach, Kulmbach, 95326, Germany|VK&K Studienzentrum Landshut am Lakumed Klinikum Landshut-Achdorf, Landshut, 84036, Germany|Praxis Dr. Müller MVM GmbH, Studienzentrum UnterEms, Leer, 26789, Germany|Universit?ts-Frauenklinik Leipzig, Leipzig, 04103, Germany|H?matologie Onkologie Gemeinschaftspraxis Pasing, Munich, 81241, Germany|Ev. Krankenhaus Bethesda M?nchengladbach, M?nchengladbach, 41061, Germany|MVZ Nordhausen gGmbH, Nordhausen, 99734, Germany|Klinikum Nürnberg, Nuremberg, 90419, Germany|Frauenklinik, Medius Klinik Nürtingen, Nürtingen, 72622, Germany|Gemeinschaftspraxis für H?matologie und Onkologie GbR, Ravensburg, 88212, Germany|Frauenklinik, Diakoniekrankenhaus Rotenburg, Rotenburg, 27356, Germany|Leopoldina Krankenhaus der Stadt Schweinfurt gGmbH, Schweinfurt, 97422, Germany|Schwerpunktpraxis für H?matologie, Onkologie und Magen-Darm Diagnostik, Singen, 78224, Germany|Onkologische Schwerpunktpraxis Speyer, Speyer, 61346, Germany|Klinikum Stuttgart, Stuttgart, 70174, Germany|Onkologie Rheinsieg, Praxisnetzwerk H?matologie und internistische Onkologie, Troisdorf, 53840, Germany|Universitaetsklinikum Tuebingen, Tuebingen, 72076, Germany|Universit?ts-Frauenklinik Ulm, Ulm, 89075, Germany|MVZ Nordoberpfalz, Weiden, 92637, Germany|Medizinische Studiengesellschaft Nord-West GmbH, Westerstede, 26655, Germany|Rems-Murr Kliniken Winnenden, Winnenden, 71364, Germany Less << |
NCT03179956 | Squamous Cell Carcinoma of the... More >> Head and Neck Less << | EARLY_PHASE1 | TERMINATED | 2019-01-10 | Fox Chase Cancer Center, Phila... More >>delphia, Pennsylvania, 19111, United States Less << |
NCT02187783 | Tumors With CDK4/6 Pathway Act... More >>ivation Less << | PHASE2 | COMPLETED | 2018-01-17 | University of Alabama at Birmi... More >>ngham, Birmingham, Alabama, 35249, United States|Alaska Clinical Research, Anchorage, Alaska, 99503, United States|Arizona Oncology Associates Dept. Of Onc., Phoenix, Arizona, United States|University of Arkansas/ Arkansas Cancer Research Center UA Medical Sciences, Little Rock, Arkansas, 72205, United States|PCR Oncology, Pismo Beach, California, 93449, United States|University of California Davis Cancer Center UC Davis Cancer (3), Sacramento, California, 95817, United States|Sarah Cannon Research Institute, Denver, Colorado, 80218, United States|Danbury Hospital, Danbury, Connecticut, 06810, United States|Yale University School of Medicine Smilow Cancer Hospital, New Haven, Connecticut, 06520, United States|Whittingham Cancer Center Norwalk Hospital, Norwalk, Connecticut, 06856, United States|Stamford Hospital Med. Oncology Hematology Res., Stamford, Connecticut, 06902, United States|Florida Hospital Cancer Institute, Orlando, Florida, 32804, United States|NorthWest Georgia Oncology Centers NW Georgia Oncology, Marietta, Georgia, 30060, United States|Harbin Clinic Medical Oncology Clin. Res., Rome, Georgia, 30165, United States|Queen's Medical Center Queens Cancer Center, Honolulu, Hawaii, 96817, United States|Northwestern Medicine Developmental Therapeutics Institute, Chicago, Illinois, 60611, United States|Indiana University Indiana Univ. - Purdue Univ., Indianapolis, Indiana, 46202, United States|Northern Indiana Cancer Research Consortium No. Indiana Cancer Res., South Bend, Indiana, 46617, United States|University of Iowa Hospitals & Clinics Regulatory Contact 2, Iowa City, Iowa, 52242, United States|New England Cancer Specialists, Scarborough, Maine, 04074, United States|St. Agnes Hospital St. Agnes Hospital (2), Baltimore, Maryland, 21229, United States|Michigan Medicine University of Michigan Int. Medicine Oncology, Ann Arbor, Michigan, 48109 5271, United States|Cancer and Hematology Centers of West Michigan Dept. of Oncology, Grand Rapids, Michigan, 49546, United States|Saint Luke's Hospital/Marion Bloch Neuroscience Institute St. Luke's Hospital (4), Kansas City, Missouri, 64111, United States|Research Medical Center Research Med Center (2), Kansas City, Missouri, 64132, United States|Comprehensive Cancer Centers of Nevada CCC of Nevada- Southwest (2), Las Vegas, Nevada, 89109, United States|Cooper Health System Cooper Health System (5), Camden, New Jersey, 08103, United States|Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, 08903, United States|New Mexico Cancer Care Alliance, Albuquerque, New Mexico, 87106, United States|Cancer Center at Presbyterian, Albuquerque, New Mexico, United States|Broome Oncology Broome Oncology (2), Johnson City, New York, 13790, United States|University of N C at Chapel Hill Physician Office Building, Chapel Hill, North Carolina, 27599-7600, United States|Carolina Oncology Specialists, PC, Hickory, North Carolina, 28602, United States|Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina, 27157, United States|Oncology Hematology Care Inc Oncology Hematology Care 2, Cincinnati, Ohio, 45242, United States|Cleveland Clinic Foundation Taussig Cancer Institute, Cleveland, Ohio, 44195, United States|Ohio State University Medical Center Comprehensive Cancer Center, Columbus, Ohio, 43221, United States|Oregon Health and Science University Oregon Health & Science U (56), Portland, Oregon, 97239, United States|Salem Health, Salem, Oregon, 97309, United States|Fox Chase Cancer Center Dept of Medical Oncology, Philadelphia, Pennsylvania, 19111, United States|Rhode Island Hospital Rhode Island Hosp. (2), Providence, Rhode Island, 02903, United States|Greenville Health System ITOR - Cancer Institute, Greenville, South Carolina, 29615, United States|Sanford University of South Dakota Medical Center Sanford Health, Sioux Falls, South Dakota, 57104, United States|Chattanooga Oncology and Hematology Assoicates, PC Chattanooga Oncology, Chattanooga, Tennessee, 37404, United States|The West Clinic Dept. of the West Clinic, Memphis, Tennessee, 38120, United States|Tennessee Oncology Tennessee Oncology (3), Nashville, Tennessee, 37203, United States|Coastal Bend Cancer Center, Corpus Christi, Texas, 78404, United States|Oncology Consultants Oncology Group, Houston, Texas, 77024, United States|MD Anderson Cancer Center/University of Texas MD Anderson Cancer Center (3), Houston, Texas, 77030, United States|University of Texas Health Science Center at San Antonio Cancer Therapy & Research Ctr., San Antonio, Texas, 78229, United States|Intermountain Medical Center Intermountain Healthcare, Murray, Utah, 84157, United States|Utah Cancer Specialists Utah Cancer Specialists (11), Salt Lake City, Utah, 84106, United States|Shenandoah Oncology Shenadoah Oncology (2), Winchester, Virginia, 22601, United States|Kadlec Clinic Hematology and Oncology Kadlec Clinic Hematology & Onc, Kennewick, Washington, 99336, United States|Vista Oncology Inc. PS, Olympia, Washington, 98502, United States|Multicare Research Institute, Tacoma, Washington, 98405, United States|Northwest Medical Specialties Rainier Physicians, PC, Tacoma, Washington, 98405, United States|Providence St. Mary Regional Cancer Center, Walla Walla, Washington, 98057, United States|Wenatchee Valley Medical Center Wenatchee Valley, Wenatchee, Washington, 98801, United States|Aurora Research Institute Aurora Health Care, Milwaukee, Wisconsin, 53226, United States|Medical College of Wisconsin Cancer Center, Milwaukee, Wisconsin, 53226, United States Less << |
NCT02934568 | Continued Access to Study Trea... More >>tment(s), Cancers With a Mass, Bulky Tumor, Nodule, Lump, Advanced Cancer, Advanced Solid Tumors, Advanced Solid Malignancies Less << | PHASE2 | RECRUITING | 2026-09-01 | University Of Alabama At Birmi... More >>ngham, Birmingham, Alabama, 35294-3300, United States|Dana Farber Cancer Institute Main Site, Boston, Massachusetts, 02215, United States|The Regents of the University of Michigan, Ann Arbor, Michigan, 48109-5930, United States|Broome Oncology SC-2, Johnson City, New York, 13790, United States|St Jude Childrens Research Hospital, Memphis, Tennessee, 38105, United States|Novartis Investigative Site, Lyon, 69373, France|Novartis Investigative Site, Villejuif, 94800, France|Novartis Investigative Site, Singapore, 119228, Singapore|Novartis Investigative Site, Barcelona, Catalunya, 08035, Spain|Novartis Investigative Site, Madrid, 28041, Spain|Novartis Investigative Site, Madrid, 28050, Spain|Novartis Investigative Site, Tainan, 70403, Taiwan|Novartis Investigative Site, Taipei, 10002, Taiwan Less << |
NCT01237236 | Advanced Solid Tumor|Lymphomas | PHASE1 | COMPLETED | 2017-03-09 | Dana Farber Cancer Institute D... More >>FCI, Boston, Massachusetts, 02215, United States|University of Michigan Comprehensive Cancer Center SC, Ann Arbor, Michigan, +1 48109 0944, United States|Memorial Sloan Kettering MSKCC (2), New York, New York, 10017, United States|Sarah Cannon Research Institute DeptofSarahCannonRes.Inst. (2), Nashville, Tennessee, 37203, United States|Novartis Investigative Site, Lyon Cedex, 69373, France|Novartis Investigative Site, Villejuif Cedex, 94805, France|Novartis Investigative Site, Utrecht, 3584CX, Netherlands Less << |
NCT02429089 | Squamous Cell Carcinoma of the... More >> Head and Neck Less << | PHASE1 | TERMINATED | 2018-09-01 | Grand H?pital de Charleroi sit... More >>e Notre Dame, Charleroi, Hainaut, 6000, Belgium|H?pital de Jolimont, Haine-Saint-Paul, Hainaut, 7100, Belgium|Cliniques universitaires Saint-Luc, Brussel, 1200, Belgium|Universitair Ziekenhuis Gent, Gent, 9000, Belgium|Clinique et Maternité Sainte-Elisabeth, Namur, 5000, Belgium Less << |
NCT05569187 | Breast Cancer | COMPLETED | 2021-10-29 | Novartis Investigative Site, S... More >>ao Paulo, SP, 01317 000, Brazil Less << | |
NCT01747876 | Malignant Rhabdoid Tumors (MRT... More >>)|Neuroblastoma Less << | PHASE1 | TERMINATED | 2017-06-29 | UCSF Medical Center Dept of Pe... More >>diatic Oncology, San Francisco, California, 94143, United States|Childrens Healthcare of Atlanta Dept of Oncology, Atlanta, Georgia, 30342, United States|Dana Farber Cancer Institute SC-7, Boston, Massachusetts, 02215, United States|Memorial Sloan Kettering Dept of Onc, New York, New York, 10017, United States|Cincinnati Children's Hospital Medical Center Dept of Oncology, Cincinnati, Ohio, 45229-3039, United States|St Jude s Childrens Research Hospital Dept of Oncology, Memphis, Tennessee, 38105-2794, United States|Novartis Investigative Site, Perth, Western Australia, 6840, Australia|Novartis Investigative Site, Lyon Cedex, 69373, France|Novartis Investigative Site, Paris, 75231, France|Novartis Investigative Site, Villejuif Cedex, 94805, France|Novartis Investigative Site, Koeln, Nordrhein-Westfalen, 50937, Germany|Novartis Investigative Site, Augsburg, 86156, Germany|Novartis Investigative Site, Sutton, Surrey, SM2 5PT, United Kingdom Less << |
NCT02345824 | Glioblastoma|Glioma | PHASE1 | UNKNOWN | 2025-01-20 | University of Virginia Health ... More >>System, Charlottesville, Virginia, 22908, United States Less << |
NCT02933736 | Glioblastoma Multiforme|Mening... More >>ioma Less << | EARLY_PHASE1 | ACTIVE_NOT_RECRUITING | 2025-01-25 | Barrow Brain and Spine, Phoeni... More >>x, Arizona, 85013, United States Less << |
NCT02607124 | High Grade Glioma|Diffuse Intr... More >>insic Pontine Glioma|Bithalamic High Grade Glioma Less << | PHASE1|PHASE2 | TERMINATED | 2025-08-18 | Cincinnati Children's Hospital... More >> Medical Center, Cincinnati, Ohio, 45229, United States Less << |
NCT01898845 | Advanced Solid Tumors | PHASE1 | COMPLETED | 2025-01-15 | Novartis Investigative Site, K... More >>ashiwa, Chiba, Japan|Novartis Investigative Site, Chuo-ku, Tokyo, Japan Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.30mL 0.46mL 0.23mL |
11.51mL 2.30mL 1.15mL |
23.01mL 4.60mL 2.30mL |
Tags: Ribociclib | LEE011 | LEE 011 | LEE-011 | CDK | Cyclin dependent kinase | CDK4 inhibitor | CDK6 inhibitor | G1 phase cell cycle arrest | cell cycle regulation | 1211441-98-3
Precautionary Statements-General | |
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Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
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P337 | If eye irritation persists: |
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P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
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P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
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P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
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P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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