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Chemistry
Organic Building Blocks
Aryls
2-Chloro-1,3-difluoro-4-(trifluoromethyl)benzene
Chemistry
Organic Building Blocks
Aryls
Chlorides Fluorinated Building Blocks Trifluoromethyls Benzene Compounds
Alternatived Products of [ 120770-03-8 ]
Product Citations

Product Details of [ 120770-03-8 ]

CAS No. :120770-03-8 MDL No. :MFCD04972709
Formula : C7H2ClF5 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 216.54 Pubchem ID :-
Synonyms :

Safety of [ 120770-03-8 ]

Signal Word: Class:
Precautionary Statements: UN#:
Hazard Statements: Packing Group:

Application In Synthesis of [ 120770-03-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 120770-03-8 ]

[ 120770-03-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 126-33-0 ]
  • [ 61841-45-0 ]
  • [ 393-01-1 ]
  • [ 120770-03-8 ]
YieldReaction ConditionsOperation in experiment
With potassium fluoride; 3-Chloro-2,4-difluoro-benzotrifluoride 3,700 g of potassium fluoride are initially introduced into 10,000 ml of tetramethylene sulphone in a stirred apparatus with exclusion of moisture, and 500 ml of tetramethylene sulphone are distilled off under a pressure of 16 mbar. 3,965 g of 2,3,4-trichlorobenzotrifluoride are then metered in and the mixture is heated to 230 C. The product formed is taken off via a column with a reflux divider. After three hours, a slight vacuum is applied and the mixture is subjected to incipient distillation up to the boiling point of tetramethylene sulphone. The coarse distillate (3,390 g) is subjected to fine distillation. The first runnings of 396 g comprise mainly 2,3,4-trifluoro-benzotrifluoride (boiling point 92-142 C.; the main runnings (3,051 g) have a boiling point of 142-143 C. and comprise 3-chloro-2,4-difluorobenzotrifluoride to the extent of 97.6%.
Reference： [1]Patent: US5599980,1997,A
  • 2
  • [ 126-33-0 ]
  • [ 61841-45-0 ]
  • [ 120770-03-8 ]
YieldReaction ConditionsOperation in experiment
With potassium fluoride; 3-Chloro-2,4-difluoro-benzotrifluoride 800 g of potassium fluoride and 2500 ml of tetramethylene sulphone are initially introduced into a stirred apparatus and the mixture is subjected to incipient distillation under a pressure of 15 mbar until about 200 ml of solvent have passed over. 1100 g of 2,3,4-trichlorobenzotrifluoride are then metered in at a temperature of 150 C. and the mixture is heated to 220 C. with exclusion of moisture. The product is taken off over a column with a reflux divider; the mixture is kept at this temperature for a total of 12 hours. The content of fluoroaromatics is then distilled off under reduced pressure. After redistillation of the reaciton mixture, 652 g of 3-chloro-2,4-difluoro-benzotrifluoride are obtained, after first runnings comprising 2,3,4-trifluoro-benzotrifluoride, in a boiling range of 37-40 C./16 mbar.
Reference： [1]Patent: US5599980,1997,A

Tags: 120770-03-8 synthesis path| 120770-03-8 SDS| 120770-03-8 COA| 120770-03-8 purity| 120770-03-8 application| 120770-03-8 NMR| 120770-03-8 COA| 120770-03-8 structure

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Technical Information

• Alkyl Halide Occurrence • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Friedel-Crafts Reaction • General Reactivity • Grignard Reaction • Hiyama Cross-Coupling Reaction • Hydrogenolysis of Benzyl Ether • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Preparation of Alkylbenzene • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Vilsmeier-Haack Reaction
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