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Chemical Structure| 1202551-28-7 Chemical Structure| 1202551-28-7

Structure of 1202551-28-7

Chemical Structure| 1202551-28-7

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Product Details of [ 1202551-28-7 ]

CAS No. :1202551-28-7
Formula : C17H18ClN3O2S
M.W : 363.86
SMILES Code : CCS(=O)(NCC1=CC(C(N2C)=CC3=C2C=C(Cl)C=C3)=CN=C1)=O

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Application In Synthesis of [ 1202551-28-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1202551-28-7 ]

[ 1202551-28-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1520-70-3 ]
  • [ 1202551-93-6 ]
  • [ 1202551-28-7 ]
YieldReaction ConditionsOperation in experiment
A flask is charged with 6-chloro-2-(5-formyl-pyridin-3-yl)-1-methyl-1 H-indole (Example 126a, 1.2 g, 4.43 mmol), <strong>[1520-70-3]ethanesulfonamide</strong> (0.726 g, 6.65 mmol), titanium(IV) isopropoxide (2.60 ml_, 8.87 mmol) and toluene (50 ml_). The reaction mixture is refluxed overnight and then concentrated to dryness. The crude material (1.60 g) is dissolved in MeOH (24 mL) and DCM (24 ml_), and sodium borohydride (0.335 g, 8.87 mmol) is added. The reaction mixture is stirred at room temperature for 2 h, then concentrated in vacuo. The residue is taken up in DCM and washed with water twice. The organic layer is dried over sodium sulfate, filtered and concentrated in vacuo. Purification is achieved by silica gel flash chromatograpy to give Lambda/-[5-(6-Chloro-1-methyl-1 H-indol-2-yl)-pyridin- 3-ylmethyl]-<strong>[1520-70-3]ethanesulfonamide</strong>. 1H NMR (400 MHz, MeOD) delta ppm 1.38 (t, J=7.3 Hz, 3 H), 3.14 (q, J=7.3 Hz, 2 H), 3.80 (s, 3 H), 4.43 (s, 2 H), 6.72 (s, 1 H), 7.12 (dd, J=Q.5, 1.9 Hz, 1 H), 7.54 (d, J=1.8 Hz, 1 H), 7.59 (d, J=8.6 Hz, 1 H), 8.10 (t, ./=2.1 Hz, 1 H), 8.63 (d, J=2.0 Hz, 1 H), 8.71 (d, J=2.0 Hz, 1 H). HRMS (ESI) m/z 364.0869 [(M+H)+ Calcd for C17H19CIN3O2S: 364.0887].
  • 2
  • [ 352359-22-9 ]
  • [ 1202551-28-7 ]
 

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