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Chemical Structure| 1202550-93-3 Chemical Structure| 1202550-93-3

Structure of 1202550-93-3

Chemical Structure| 1202550-93-3

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Product Details of [ 1202550-93-3 ]

CAS No. :1202550-93-3
Formula : C18H17ClN4O2S
M.W : 388.87
SMILES Code : CCS(=O)(NCC1=CC(C(N2C)=C(C#N)C3=C2C=C(Cl)C=C3)=CN=C1)=O

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Application In Synthesis of [ 1202550-93-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1202550-93-3 ]

[ 1202550-93-3 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1520-70-3 ]
  • [ 1202550-44-4 ]
  • [ 1202550-93-3 ]
YieldReaction ConditionsOperation in experiment
6-Chloro-2-(5-formyl-pyridin-3-yl)-1-methyl-1 H-inclole-3-carbonitpile (Example 126b, 2.0 g, 6.09 mmol), <strong>[1520-70-3]ethanesulfonamide</strong> (1.33 g, 12.17 mmol) and toluene (250 mL), and titanium(IV) isopropoxide (2.59 g, 9.13 mmol) is added dropwise. The mixture is stirred at 120 0C overnight. The mixture is then concentrated in vacuo. The residue is taken up in DCM (15O mL) and MeOH (15O mL), and NaBH4 (0.461 g, 12.17 mmol) is added at 0 0C. The mixture is stirred at 0 0C for 30 min. Water (50 mL) is added and the mixture is stirred for 5 min. The suspension is filtered through a pad of celite. The celite layer is washed with DCM (3 x 50 mL). The combined organic phase is dried over Na2SO4 and concentrated to give a residue is purified by silica gel flash chromatography (ethyl acetate). The resulting fractions containing the product are concentrated and repurified by silica gel flash chromatography (dichloromethane-methanol, 1 :0 to 97:3). The concentrated product is redissolved in MeOH (500 mL) at 60 0C and concentrated in vacuo to give Lambda/-[5-(6-chloro-3-cyano-1-methyl-1 H-indol-2-yl)-pyridin-3-ylmethyl]- <strong>[1520-70-3]ethanesulfonamide</strong>. 1H NMR (400 MHz, DMSO-cfe) delta ppm 1.20 (t, J=7.3 Hz, 3 H), 3.06 (q, J=7.3 Hz, 2 H), 3.78 (s, 3 H), 4.34 (d, J=6.3 Hz, 2 H), 7.37 (dd, J=8.6, 1.8 Hz, 1 H), 7.73 (d, J=8.3 Hz, 1 H), 7.77 (t, J=6.2 Hz, 1 H), 7.97 (d, J=1.8 Hz, 1 H), 8.09 (t, J=2.1 Hz, 1 H), 8.78 (d, J=1.8 Hz, 1 H), 8.80 (d, J=1.8 Hz, 1 H). HRMS (ESI) m/z 389.0853 [(M+H)+ Calcd for C18H17CIN4O2S: 389.0839].
 

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