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Chemical Structure| 1200131-21-0 Chemical Structure| 1200131-21-0

Structure of 1200131-21-0

Chemical Structure| 1200131-21-0

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Product Details of [ 1200131-21-0 ]

CAS No. :1200131-21-0
Formula : C13H18BrNO
M.W : 284.19
SMILES Code : COC1=CC(Br)=CC(CN2CCCCC2)=C1
MDL No. :MFCD28401507

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Application In Synthesis of [ 1200131-21-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1200131-21-0 ]

[ 1200131-21-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 110-89-4 ]
  • [ 262450-65-7 ]
  • [ 1200131-21-0 ]
YieldReaction ConditionsOperation in experiment
69% To a pre-stirred solution of <strong>[262450-65-7]3-bromo-5-methoxybenzaldehyde</strong> (0.56 g, 2.61 mmol) and piperidine (0.29 mL, 3.93 mmol) in DCM (10 mL) at 0 C was added sodium borohydride (197 mg, 5.22 mmol) in portions. The reaction mixture was allowed to warm to ambient temperature and stirred for an additional 2 h. The reaction was quenched by the addition of water (30 mL) and extracted into ethyl acetate (75 mL) then washed with water (50 mL) then the organic phase was dried over anhydrous sodium sulfate, filtered and evaporated in vacuo to afford the title compound as a colourless oil (510 mg, 69%) that was used in the next step without further purification. 1H NMR (CDCl3, 400MHz): 7.08-7.06 (m, 1H), 6.94-6.91 (m, 1H), 6.83-6.80 (s, 1H), 3.79 (s, 3H), 3.39 (s, 2H), 2.40-2.30 (s, 4H), 1.61-1.51 (m, 4H), 1.47-1.38 (m, 2H).
 

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