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Chemical Structure| 1199942-97-6 Chemical Structure| 1199942-97-6

Structure of 1199942-97-6

Chemical Structure| 1199942-97-6

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Product Details of [ 1199942-97-6 ]

CAS No. :1199942-97-6
Formula : C12H9N3O2
M.W : 227.22
SMILES Code : O=C1C2=CC=NC2N=C(C3=CC=C(O)C=C3)N1

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Application In Synthesis of [ 1199942-97-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1199942-97-6 ]

[ 1199942-97-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 52133-67-2 ]
  • [ 38148-63-9 ]
  • [ 1199942-97-6 ]
YieldReaction ConditionsOperation in experiment
4-Hydroxybenzamidine hydrochloride (15.2 g) was dissolved in absolute ethanol (520 ml.) and a part of the ethanol (370 ml.) was subsequently distilled off again. More absolute ethanol (370 ml.) was added to this receiving solution, together with DBU (30 ml_), <strong>[52133-67-2]2-cyano-4,4-diethoxy-butyric acid ethyl ester</strong> (40.0 g) and triethyl amine (26 ml_). The resulting mixture was heated until reflux and further refluxed for 45 hours ("hrs"). Most of the solvent (430 ml.) was then distilled off while the remainder was allowed to cool to 50 0C. An aqueous solution of hydrochloric acid (2.3 M, 229 ml.) was added dropwise, then the reaction mixture was allowed to cool to ambient temperature and stirring was continued for 1 hr. The resulting precipitate was filtered off, washed with water (3 x 100 ml.) and dried in vacuo at 40 0C to yield 16.0 g 2-(4-hydroxy-phenyl)-7/-/-pyrrolo[2,3-d]pyrimidin-4-ol
 

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