Home Cart Sign in  
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 1196-19-6 Chemical Structure| 1196-19-6
Chemical Structure| 1196-19-6

*Storage: Inert atmosphere,Store in freezer, under -20°C.

3-(Bromomethyl)benzo[b]thiophene

CAS No.: 1196-19-6

4.5 *For Research Use Only !

Cat. No.: A225575 Purity: 95%

Change View

Size Price

USA Stock *0-1 Day

Global Stock *5-7 Days

In Stock
100mg łďÿ¶ÊÊ In Stock In Stock Login
250mg łÇǧ¶ÊÊ In Stock In Stock Login
1g ł§ÍǶÊÊ In Stock In Stock Login

Please Login or Create an Account to: See VIP prices and availability

  • 100mg

    łďÿ¶ÊÊ

  • 250mg

    łÇǧ¶ÊÊ

  • 1g

    ł§ÍǶÊÊ

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

  • 1-2 Day Shipping
  • High Quality
  • Technical Support Online Technical Q&A
Product Citations

Product Details of [ 1196-19-6 ]

CAS No. :1196-19-6
Formula : C9H7BrS
M.W : 227.12
SMILES Code : BrCC1=CSC2=CC=CC=C21
MDL No. :MFCD00098683
InChI Key :WYKHJZSILIVQKU-UHFFFAOYSA-N
Pubchem ID :11264641

Safety of [ 1196-19-6 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314
Precautionary Statements:P501-P260-P270-P264-P280-P303+P361+P353-P301+P330+P331-P363-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P405
Class:8
UN#:1759
Packing Group:

Application In Synthesis [ 1196-19-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1196-19-6 ]

[ 1196-19-6 ] Synthesis Path-Upstream   1~4

  • 1
  • [ 5381-24-8 ]
  • [ 1196-19-6 ]
YieldReaction ConditionsOperation in experiment
73% With phosphorus tribromide In diethyl ether at 0 - 20℃; for 1.25 h; B. To a stirred solution of benzothien-3-ylmethanoi (400 mg, 2.44 mmol) in ether (12 ml_) at 00C was added PBr3 (0.23 mL, 2.42 mmol) dropwise. The mixture was stirred at 00C for 30 min. and then at ambient temperature for 45 min. The reaction mixture was poured into a mixture of ice water and ether. The organic phase was separated and washed with brine, dried and concentrated to give 3-(bromomethyl)benzothiophene as a pale solid (404 mg, 73percent).
References: [1] Patent: WO2008/110793, 2008, A1, . Location in patent: Page/Page column 111.
[2] Patent: US2009/176996, 2009, A1, . Location in patent: Page/Page column 15-16.
  • 2
  • [ 5381-20-4 ]
  • [ 1196-19-6 ]
YieldReaction ConditionsOperation in experiment
70%
Stage #1: at 0℃; for 1 h;
Stage #2: With carbon tetrabromide; triphenylphosphine In dichloromethane for 1 h; Inert atmosphere
To a solution of l-benzothiophene-5-carbaldehyde (800 mg, 5 mmol) in MeOH (10 mL) was added sodium tetrahydroborate (0.28 g, 7.4 mmol) at 0 °C. The reaction mixture was allowed to stir at 0 °C for lh, at which point a saturated aqueous solution of H4C1 (50 mL) and water (50 mL) was added. The mixture was extracted with DCM (3x). The organic solutions were combined, dried over MgS04, filtered, and concentrated to dryness. The crude solid was then dissolved in DCM (100 mL) under argon and triphenyl phosphine (2.30 g, 8.78 mmol) and carbon tetrabromide (2.0 g, 5.9 mmol) were added. After stirring for lh, diethyl ether was added and the resulting mixture was filtered and washed with diethyl ether (2x). The filtrate was concentrated to dryness and the crude residue was purified by column chromatography to afford 5-(bromomethyl)-l-benzothiophene (760 mg, 70 percent) as a white solid. 1H MR (400 MHz, CDCI3) δ 7.80 - 7.92 (m, 2H), 7.51 (d, J=5.4 Hz, 1H), 7.41 (dd, J=8.3, 1.8 Hz, 1H), 7.35 (d, J=5.4 Hz, 1H), 4.68 (s, 2H).
References: [1] Patent: WO2018/89786, 2018, A1, . Location in patent: Paragraph 00376.
  • 3
  • [ 58432-15-8 ]
  • [ 1196-19-6 ]
YieldReaction ConditionsOperation in experiment
56%
Stage #1: With hydrogen bromide In water; acetone at 0℃; for 0.0833333 h; Inert atmosphere
Stage #2: With tert.-butylnitrite In water; acetone at 0℃; for 0.25 h;
Stage #3: With sodium iodide In water; acetone at 0 - 60℃; for 9 h;
General procedure: Under argon protection, under ice bath conditions,2-propargyloxyaniline compound (0.5 mmol) and acetone 3.0 mL were sequentially added to a dry reaction tube.A solution of hydrobromic acid in acetic acid (0.18 mL) was stirred for 5 minutes, then tert-butyl nitrite (0.08 mL) was added to the system.After the reaction system was stirred for 15 min in an ice bath, sodium iodide (0.2 mmol) was added, and acetone (7.0 mL) was added thereto, and the ice bath was removed, the system was heated to 60 ° C, and the reaction was finished for about 9 hours.Stirring was stopped, the solvent was removed under reduced pressure, washed with saturated aqueous sodiumDry over anhydrous sodium sulfate, remove the solvent under reduced pressure, column chromatography, eluent:Ethyl acetate and petroleum ether were collected and the corresponding product B was obtained.
References: [1] Patent: CN104987317, 2019, B, . Location in patent: Paragraph 0068; 0069; 0088; 0089; 0090.
  • 4
  • [ 1455-18-1 ]
  • [ 1196-19-6 ]
References: [1] Organic Letters, 2006, vol. 8, # 18, p. 4085 - 4088.
[2] Journal of Medicinal Chemistry, 2002, vol. 45, # 20, p. 4559 - 4570.
[3] Journal of Medicinal Chemistry, 1991, vol. 34, # 1, p. 65 - 73.
[4] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 14, p. 5291 - 5300.
[5] Organic Letters, 2013, vol. 15, # 16, p. 4194 - 4197.
[6] European Journal of Organic Chemistry, 2014, vol. 2014, # 16, p. 3402 - 3410.
 

Related Products

Historical Records

Technical Information

Categories