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Chemical Structure| 1187450-90-3 Chemical Structure| 1187450-90-3

Structure of 1187450-90-3

Chemical Structure| 1187450-90-3

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Product Details of [ 1187450-90-3 ]

CAS No. :1187450-90-3
Formula : C10H9NOS
M.W : 191.25
SMILES Code : OCC1=CC=C(C2=CSC=N2)C=C1
MDL No. :MFCD30078476

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Application In Synthesis of [ 1187450-90-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1187450-90-3 ]

[ 1187450-90-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 59016-93-2 ]
  • [ 34259-99-9 ]
  • [ 1187450-90-3 ]
YieldReaction ConditionsOperation in experiment
75% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,4-dioxane; water; at 100℃; Aqueous potassium carbonate solution (3.0 M, 17 mL, 51 mmol) was added to a solution of [4-(hydroxymethyl)phenyl]boronic acid (96percent, 4.0 g, 25 mmol) and 4-bromo- 1 ,3-thiazole (96percent, 6.48 g, 37.9 mmol) in 1 ,4-dioxane (75 mL). Tetrakis(triphenylphosphine)palladium(0) (885 mg, 0.766 mmol) was added, and thereaction mixture was heated at 100 00 overnight. After cooling to room temperature, the reaction mixture was diluted with water and extracted several times with ethyl acetate. The combined organic layers were washed with saturated aqueous sodium chloride solution, dried over magnesium sulfate, filtered, and concentrated in vacuo; silica gel chromatography (Gradient: 25percent to 50percent ethyl acetate in heptane) provided the productas a cream-colored solid. Yield: 3.60 g, 18.8 mmol, 75percent. LCMS m/z 192.0 [M+H]. 1H NMR (400 MHz, ODd3) oe 8.92 (d, J=2.0 Hz, 1 H), 7.95 (br d, J=8.2 Hz, 2H), 7.56 (d, J=2.0 Hz, 1H), 7.46 (br d, J=8.3 Hz, 2H), 4.76 (5, 2H).
 

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