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Chemical Structure| 1182443-71-5 Chemical Structure| 1182443-71-5

Structure of 1182443-71-5

Chemical Structure| 1182443-71-5

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Product Details of [ 1182443-71-5 ]

CAS No. :1182443-71-5
Formula : C9H11FN2O3
M.W : 214.19
SMILES Code : O=[N+](C1=C(F)C=CC=C1NCCOC)[O-]
MDL No. :MFCD12149669

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Application In Synthesis of [ 1182443-71-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1182443-71-5 ]

[ 1182443-71-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 19064-24-5 ]
  • [ 109-85-3 ]
  • [ 1182443-71-5 ]
YieldReaction ConditionsOperation in experiment
71.2% In tetrahydrofuran; at 20℃; for 9.33333h; EXAMPLE 715-(4-{4-f|UOro-1 -[2-(methyloxy)ethyl]-1 H-benzimidazol-2-yl}-1 H-imidazol-2-yl)-1 ,3- benzothiazole trifluoroacetateStep 1 . (3-fluoro-2-nitrophenyl)[2-(methyloxy)ethyl]amine: To a solution of 2,6- difluorodinitrobenzene (4 g, 24.64 mmol) in Tetrahydrofuran (THF) (80 ml) at rt was added 2-methoxyethlyamine (2.164 ml, 24.64 mmol). This was stirred at rt for 80 min, at which time, LCMS showed nearly half complete. Allowed to stir for 8 hr. LCMS showed 12%sm, 85% product, and 3% double addition product. Diluted with Et20 and water, separated layers and back-extracted with Et20 twice. Washed with Brine and dried on MgS04. Filtered and concentrated. Purified via Biotage FCC (40 g SNAP column, 0-10%EtOAC/hex); baseline separation was acheived. Combined an concentrated product fractions to provide (3-fluoro-2-nitrophenyl)[2-(methyloxy)ethyl]amine (3.76 g, 17.55 mmol, 71 .2 % yield) as a bright orange oil. MS (m/z) 215.0 (M+H)+.
 

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