Home Cart Sign in  
Chemical Structure| 1177415-97-2 Chemical Structure| 1177415-97-2

Structure of 1177415-97-2

Chemical Structure| 1177415-97-2

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 1177415-97-2 ]

CAS No. :1177415-97-2
Formula : C12H6Cl2FN5O
M.W : 326.11
SMILES Code : FC1=C(NC(=O)C2=CN=C3N2N=C(Cl)C=C3Cl)C=CN=C1
MDL No. :MFCD17392843

Safety of [ 1177415-97-2 ]

Application In Synthesis of [ 1177415-97-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1177415-97-2 ]

[ 1177415-97-2 ] Synthesis Path-Downstream   1~1

  • 1
  • C7H2BrCl2N3O*(x)ClH [ No CAS ]
  • C7H2Cl3N3O*(x)ClH [ No CAS ]
  • [ 2247-88-3 ]
  • [ 1177415-97-2 ]
  • [ 1177415-98-3 ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 20℃; A 250 mL round bottomed flask was charged with a mixture of 6,8- dichloroimidazo[l,2-b]pyridazine-3-carboxylic acid and 8-bromo-6- chloroimidazo[l,2-b]pyridazine-3-carboxylic acid (1.0 g, 4.31 mmol) ID, 1,2- dichloroethane (33.2 mL), and DMF (0.267 mL, 3.45 mmol). To the resulting white suspension under nitrogen at room temperature was added oxalyl chloride (6.46 mL, 12.93 mmol) solution slowly via syringe, carefully monitoring gas evolution. Following cessation of bubbling, the reaction mixture was fitted with a reflux <n="56"/>condenser and heated to 65 0C for Ih, whereupon it slowly became a light yellow, homogeneous solution. The mixture was cooled to room temperature, toluene was added, and the solution was concentrated in vacuo. (This process was repeated two more times to remove excess oxalyl chloride.) The resulting solid was dried in vacuo. The light yellow solid was then suspended in 1 ,2-dichloroethane (33.2 mL) and charged with <strong>[2247-88-3]3-fluoropyridin-4-amine</strong> (1.160 g, 10.34 mmol) and DIEA (4.52 mL, 25.9 mmol). The resulting light tan suspension stirred overnight at room temperature. The light brown suspension was filtered and washed with copious amounts of dichloromethane, which furnished a mixture of 6,8-dichloro-N-(3-fluoropyridin-4- yl)imidazo[l,2-b]pyridazine-3-carboxamide and 8-bromo-6-chloro-N-(3- fluoropyridin-4-yl)imidazo[l,2-b]pyridazine-3-carboxamide (1.240 g, 84 percent yield) as a tan solid. LC/MS, m/z 325.0 (M+l). HPLC Rt = 2.823 min. LC/MS, m/z 369.8 (M+l). HPLC Rt = 2.946 min. YMC S5 ODS-A column (4.6 x 50 mm). 0percent-100percentB. Solvent B: (90percent MeOH, 10percent H2O, 0.2percent H3PO4). Solvent A: (10percent MeOH, 90percent H2O, 0.2percent H3PO4). Gradient, start percent B = O, final percent B = 100, gradient time 4 min, hold at 100percent 1 min, flow rate 4 mL/min.
 

Historical Records

Technical Information

Categories