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Chemical Structure| 1177415-92-7 Chemical Structure| 1177415-92-7

Structure of 1177415-92-7

Chemical Structure| 1177415-92-7

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Product Details of [ 1177415-92-7 ]

CAS No. :1177415-92-7
Formula : C7H3Cl2N3O2
M.W : 232.02
SMILES Code : O=C(O)C1=CN=C2C(Cl)=CC(Cl)=NN21
MDL No. :MFCD31556384

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Application In Synthesis of [ 1177415-92-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1177415-92-7 ]

[ 1177415-92-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 446273-59-2 ]
  • [ 33142-21-1 ]
  • [ 1177415-91-6 ]
  • [ 1177415-92-7 ]
YieldReaction ConditionsOperation in experiment
ID: Preparation of 8-bromo-6-chloroimidazo[l,2-b] pyridazine-3-carboxylic acid and 6,8-dichloroimidazo[l,2-b]pyridazine -3-carboxylic acid[00233] To a vial was added the mixture of 1C (300 mg, 0.98 mmol) in methanol (10 mL). To this mixture was added 6 N HCl (1.64 mL, 9.85 mmol). The solution was heated at 90 0C for 16 hours. The solution was diluted with ethyl acetate, and the product extracted with saturated aqueous sodium bicarbonate solution. The combined aqueous layer was acidified with HCl (IN) to pH 4 and extracted with ethyl acetate (3 times). The ethyl acetate extracts were combined, dried over anhydrous sodium sulfate and concentrated in vacuo to give a mixture of ID-I and 1D-2 (150 mg, 55%). [00234] ID-I : HPLC: Rt = 1.67 min (Waters Sunfire Cl 8 column (4.6 x 50 mm). 10-90% aqueous methanol containing 0.1% TF A, 4 min gradient, flow rate = 4 mL/min, detection at 254 nm). MS (ES): m/z = 231.87 [M+H]+.[00235] 1D-2: HPLC: Rt = 1.81 min (Waters Sunfire C18 column (4.6 x 50 mm). 10-90% aqueous methanol containing 0.1% TF A; 4 min gradient, flow rate = 4 mL/min, detection at 254 nm). MS (ES): m/z = 275.79 [M+H]+.
 

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