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Chemical Structure| 1174662-16-8 Chemical Structure| 1174662-16-8

Structure of 1174662-16-8

Chemical Structure| 1174662-16-8

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Product Details of [ 1174662-16-8 ]

CAS No. :1174662-16-8
Formula : C18H22N2O5
M.W : 346.38
SMILES Code : CC(C)(C)C(OC1=CC2=C(N=CNC2=O)C=C1OC(C(C)(C)C)=O)=O
MDL No. :MFCD26793746

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Application In Synthesis of [ 1174662-16-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1174662-16-8 ]

[ 1174662-16-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 3282-30-2 ]
  • [ 16064-15-6 ]
  • [ 1174662-16-8 ]
YieldReaction ConditionsOperation in experiment
71% With triethylamine; In N,N-dimethyl-formamide; at 20℃; for 1h; 4-Oxo-3,4-dihydroquinazoline-6 7-diyl bis(2,2-dimethylpropanoate) To a stirred suspension of <strong>[16064-15-6]6,7-dihydroxyquinazolinone</strong> (2) (38.0 g, 213.3 mmol) and TEA (89.1 ml, 640 mmol) in DMF (200 ml), was added dropwise trimethylacetyl chloride (78.8 ml, 640 mmol). The resulting suspension was stirred at room temperature for 1 hour , diluted with EtOAc (500 ml) and washed with water (5 x 20 ml). The organic phase was concentrated to dryness and the residue triturated with water and the resulting precipitate was collected by filtration, washed with water (5 x 20 ml) and dried to a constant weight to afford the title compound (52.3 g, 71%) as a pale pink solid: LCMS (retention time = 3.65 min., purity = 100%), ESI+ mJz 347.33 (M+H)+; 'H-NMR (DMSO-d6) delta (ppm) 1.32 (s, 18H), 7.59 (s, 1H), 7.92 (s, 1H), 8.14 (s, 1H).
 

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