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Chemical Structure| 1160994-79-5 Chemical Structure| 1160994-79-5

Structure of 1160994-79-5

Chemical Structure| 1160994-79-5

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Product Details of [ 1160994-79-5 ]

CAS No. :1160994-79-5
Formula : C7H4Cl2N2O
M.W : 203.03
SMILES Code : CC1=COC2=NC(Cl)=NC(Cl)=C21
MDL No. :MFCD12400767

Safety of [ 1160994-79-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 1160994-79-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1160994-79-5 ]

[ 1160994-79-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 5117-87-3 ]
  • [ 503-38-8 ]
  • [ 1160994-79-5 ]
YieldReaction ConditionsOperation in experiment
In acetonitrile; at 95℃;In a sealed tube; To a solution of Q-1 (1.6 g, 13.1 mmol) in 13 mL ACN in a sealed tube was added diphosgene (3.9 g, 19.6 mmol) and heated to 95 C. overnight. The system was cooled to ambient temperature and the contents were partitioned between EtOAc/DCM and water, dried over MgSO4, and concentrated to afford a brown oil. To a solution of this brown oil (1.0 g, 4.9 mmol) in 30 mL EtOH was added zinc dust (2.6 g, 39.4 mmol), ammonium hydroxide (3.0 g, 24.6 mmol) and heated to 78 C. for 0.5 h. The system was then cooled and filtered through a pad of celite. The filtrate was then partitioned between EtOAc and water, dried over MgSO4, concentrated and purified via normal phase chromatography (EtOAc/hexanes) to afford Q-2 as a yellow crystalline solid. Data for Q-2: LC/MS: rt=1.65 min; m/z (M+H)=169.0 found; 169.0 required.
 

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