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Chemical Structure| 1159815-52-7 Chemical Structure| 1159815-52-7

Structure of 1159815-52-7

Chemical Structure| 1159815-52-7

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Product Details of [ 1159815-52-7 ]

CAS No. :1159815-52-7
Formula : C10H8FN3
M.W : 189.19
SMILES Code : NC1=NC(C2=CC=C(F)C=C2)=CN=C1
MDL No. :N/A

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Application In Synthesis of [ 1159815-52-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1159815-52-7 ]

[ 1159815-52-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1765-93-1 ]
  • [ 33332-28-4 ]
  • [ 1159815-52-7 ]
YieldReaction ConditionsOperation in experiment
100% With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate; In 1,4-dioxane; water; at 20℃; for 20h;Reflux; 6-Chloropyrazin-2-amine (0.96 g, 7.41 mmol) was added to a degassed suspension of Na2CO3 (2.0 M aqueous solution, 7.4 mL, 14.82 mmol), Pd(dppf)Cl2·CH2Cl2 (0.49 g, 0.59 mmol) and (4-fluorophenyl)boronic acid (1.55 g, 11.11 mmol) in 1,4-dioxane (20 mL). The reaction was refluxed for 5 h and stirred at room temperature for 15 h. The mixture was poured into water (40 mL) and extracted with Et2O. The combined organic layers were dried over Na2SO4 (anhydrous), filtered and concentrated. The crude residue was purified by flash chromatography on SiO2 (20percent to 40percent EtOAc/hexanes) to give the title compound (off-white solid, 1.5 g, quantitative yield). HPLC-MS (Method A): Ret, 8.01 min; ESI+-MS m/z: 190 (M+1).
 

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