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Chemical Structure| 1157857-87-8 Chemical Structure| 1157857-87-8

Structure of 1157857-87-8

Chemical Structure| 1157857-87-8

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Product Details of [ 1157857-87-8 ]

CAS No. :1157857-87-8
Formula : C13H9F3O2
M.W : 254.21
SMILES Code : CC(C1=CC=C(C2=CC=CC=C2C(F)(F)F)O1)=O

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Application In Synthesis of [ 1157857-87-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1157857-87-8 ]

[ 1157857-87-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 3199-50-6 ]
  • [ 1423-27-4 ]
  • [ 1157857-87-8 ]
YieldReaction ConditionsOperation in experiment
49.6% With tetrabutylammomium bromide; palladium diacetate; potassium carbonate; In water; at 70℃; for 3.33h;Inert atmosphere; General procedure: Mixtures of the aryl bromides 24 or 30 (2.65mmol), the boronic acids 23a or 23b (2.23mmol), tetrabutylammonium bromide (796mg, 2.47mmol), and K2CO3 (2.9g, 21mmol) were suspended in distilled water (10mL) under argon for 20min. Then Pd(OAc)2 (9.2mg, 0.04mmol) was added, and the resulting suspensions were heated to 70C and stirred under argon for 3h. After cooling down, the solutions were diluted with distilled water (10mL) and extracted with CH2Cl2 (3×15mL). The combined organic layers were dried over Na2SO4 and the solvents were evaporated. The crude residues were further purified by silica gel column chromatography, eluting with hexane-ethyl acetate 8:2, to provide the products 25a-b or 25d.
 

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