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Chemical Structure| 1142927-97-6 Chemical Structure| 1142927-97-6

Structure of 1142927-97-6

Chemical Structure| 1142927-97-6

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Product Details of [ 1142927-97-6 ]

CAS No. :1142927-97-6
Formula : C6H7N3
M.W : 121.14
SMILES Code : N#CCC1=NN(C)C=C1
MDL No. :MFCD18262385

Safety of [ 1142927-97-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 1142927-97-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1142927-97-6 ]

[ 1142927-97-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 38622-91-2 ]
  • [ 27258-32-8 ]
  • [ 1142927-97-6 ]
YieldReaction ConditionsOperation in experiment
48% With potassium tert-butylate; In methanol; 1,2-dimethoxyethane; at -50 - 80℃; for 1.5h;Inert atmosphere; Preparation of 2-(1 -methyl-1 -/-pyrazol-3-yl)acetonitrile A solution of tosylmethyl isocyanide (17.8 g, 91 .2 mmol) in DME (1 10 mL) under N2 was added to a suspension of i-BuOK (19.5 g, 174 mmol) in MeOH (1 10 mL) dropwise at -50 °C. A solution of 1 -methyl-1 -/-pyrazole-3-carboxaldehyde (9.57 g, 86.9 mmol) in DME (1 10 mL) was added drop wise and the reaction mixture was stirred at -50 °C for 30 min. Then MeOH (1 10 mL) was added and the reaction mixture was heated to 80 °C for 1 h. The mixture was cooled to rt and the solvents were evaporated. Water and AcOH (approx. 10 mL) were added until pH = 5-6. CH2Cl2 was added and the layers were separated. The organic layer was washed with water, dried over MgS04, filtered and evaporated in vacuo. Purification was performed by preparative silica chromatography (mobile phase gradient: from heptane/EtOAc 80/20 to 40/60) to give 2-(1 -methyl-1 /-/-pyrazol-3-yl)acetonitrile as a colorless oil.
 

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