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Chemical Structure| 1136961-91-5 Chemical Structure| 1136961-91-5

Structure of 1136961-91-5

Chemical Structure| 1136961-91-5

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Product Details of [ 1136961-91-5 ]

CAS No. :1136961-91-5
Formula : C7H4ClF3O
M.W : 196.55
SMILES Code : FC1=C(OC(F)F)C(Cl)=CC=C1
MDL No. :MFCD22580772

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1136961-91-5 ]

[ 1136961-91-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2040-90-6 ]
  • [ 1895-39-2 ]
  • [ 1136961-91-5 ]
YieldReaction ConditionsOperation in experiment
41% With potassium carbonate; In water; N,N-dimethyl-formamide; at 100℃; for 3h; 2-Chloro-6-fluorophenol (1.8 g, 12.33 mmol) was dissolved in dimethylformamide (DMF; 22 mL) and water (2.2 mL). Potassium carbonate (2.55 g, 18.5 mmol) and sodium chlorodifluoroacetate (4.7 g, 30.8 mmol) were then added and the solution was heated to 100 C. for 3 h. The cooled reaction mixture was then diluted with concentrated HCl (10 mL) and the resulting solution was stirred for 2 h. The reaction mixture was diluted with diethyl ether, washed with water, washed twice with 1M NaOH, washed once with brine, dried, filtered and concentrated under vacuum to yield the title compound (1 g, 41% yield) that was used in subsequent reactions without further purification.
 

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