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Chemical Structure| 113490-76-9 Chemical Structure| 113490-76-9

Structure of 113490-76-9

Chemical Structure| 113490-76-9

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Product Details of [ 113490-76-9 ]

CAS No. :113490-76-9
Formula : C13H17NO3
M.W : 235.28
SMILES Code : O=C(OC)[C@H]1NC[C@H](OCC2=CC=CC=C2)C1
MDL No. :MFCD09878836

Safety of [ 113490-76-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362

Application In Synthesis of [ 113490-76-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 113490-76-9 ]

[ 113490-76-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 67-56-1 ]
  • [ 40350-83-2 ]
  • [ 113490-76-9 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; at 20℃; for 12h; [1118] a mixture of <strong>[40350-83-2](2S,4R)-4-(benzyloxy)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid</strong> (500 mg, 1.56 mmol) in MeOH (3 ml), hci/MeOH (15 ml) was stirred at 20 C for 12 hours. Lcms showed starting material was consumed completely and one main peak with desired ms was detected. The reaction mixture was diluted with aqueous NaHCO3, adjusted the h ~ 7, and extracted with DCM (30 ml x 2). The combined organic layers were dried over Na2SO4, filtered and concentrated under reduced pressure to give a residue. Compound 220a (340 mg, crude, yellow oil): 1H NMR (400mhz, CDCl3) delta 7.37 - 7.20 (m, 5h), 4.52 - 4.41 (m, 2h), 4.12 (br s, 1h), 4.00 (br t, = 7.6 hz, 1h), 3.77 -3.62 (m, 3h), 3.11 (br s, 2h), 2.66 (br s, 1h), 2.29 (br dd, = 7.8, 13.1 hz, 1h), 1.98 (td, = 6.6, 13.4 hz, 1h). MS (ESI) m/z (M+H)+ 236.1.
 

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[ 113490-76-9 ]

Chemical Structure| 66831-17-2

A1363976 [66831-17-2]

(2S,4R)-Methyl 4-(benzyloxy)pyrrolidine-2-carboxylate hydrochloride

Reason: Free-salt