Home Cart Sign in  
Chemical Structure| 1112980-86-5 Chemical Structure| 1112980-86-5

Structure of 1112980-86-5

Chemical Structure| 1112980-86-5

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 1112980-86-5 ]

CAS No. :1112980-86-5
Formula : C20H14ClFN4O3S2
M.W : 476.93
SMILES Code : CC(NC1=NC2=CC=C(C3=CC(NS(=O)(C4=CC=C(F)C=C4)=O)=C(Cl)N=C3)C=C2S1)=O
MDL No. :MFCD19443166

Safety of [ 1112980-86-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 1112980-86-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1112980-86-5 ]

[ 1112980-86-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 885069-14-7 ]
  • [ 1112982-79-2 ]
  • [ 1112980-86-5 ]
YieldReaction ConditionsOperation in experiment
With sodium carbonate;Pd FibreCat; In 1,4-dioxane; water; at 20 - 100℃; Step 2. N-(6-(6-Chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)benzo[d1thiazol-2-yl)acetamide; To a solution of N-(6-(4,4,5,5-tetramethyl-l ,3,2-dioxaborolan-2-yl)benzo[d]thiazol-2-yl)acetamide (0.22 g, 0.71 mmol) and 3-[N,N-bis(4-fluorophenylsulfonyl)amino]-5-bromo-2-chloropyridine (0.37 g, 0.71 mmol) in dioxane (3 mL) was added aqueous Na2CO3 (10%, 1.0 mL) followed by Pd FibreCat(Anchored homogeneous catalyst, Johnson Matthey, West Deptford, NJ)(20 mg) in a microwave vial. <n="85"/>The reaction was heated to 100 C for 12 minutes. The mixture was then filtered. The filtrate was diluted with NaHCO3 (40 mL) and of EtOAc (60 mL). The organic phase was separated, washed with brine (30 mL), dried over Na2SO4 and concentrated in vacuo. The residue was purified by a prep-HPLC to give the desired product as light yellow solid (0.010 g). The filtered solid, mainly the bis(sulfonamide), was stirred in a mixture of dioxane (20 mL) and aqueous Na2CO3 (10%) at rt. After the completion of the reaction, the solid was collected and recrystallized in MeOH/CHCl3 solution to give additional N-(6-(6-chloro-5-(4-fluorophenylsulfonamido)pyridin-3- yl)benzo[d]thiazol-2-yl)acetamide (0.10 g). MS (ESI pos. ion) m/z: calc'd for C20Hi4ClFN4O3S2 : 476.0; found: 476.9 (MH+). 1H NMR (300 MHz, DMSO-d6) delta ppm 2.23 (s, 3 H) 7.44 (t, J=8.77 Hz, 2 H) 7.67 - 7.77 (m, 1 H) 7.77 - 7.89 (m, 3 H) 8.04 (d, J=2.05 Hz, 1 H) 8.35 (d, J=I .46 Hz, 1 H) 8.64 (d, J=2.19 Hz, 1 H) 10.50 (s, l H) 12.46 (s, 1 H).
  • 2
  • [ 885069-14-7 ]
  • [ 1112980-86-5 ]
 

Historical Records

Technical Information

Categories