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Chemical Structure| 110284-76-9 Chemical Structure| 110284-76-9

Structure of 110284-76-9

Chemical Structure| 110284-76-9

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Product Details of [ 110284-76-9 ]

CAS No. :110284-76-9
Formula : C13H12N2O4
M.W : 260.25
SMILES Code : O=CC1=CC=CC=C1OC2=NC(OC)=CC(OC)=N2

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Application In Synthesis of [ 110284-76-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 110284-76-9 ]

[ 110284-76-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 90-02-8 ]
  • [ 108279-89-6 ]
  • [ 110284-76-9 ]
YieldReaction ConditionsOperation in experiment
56.9% In N-methyl-acetamide; REFERENTIAL EXAMPLE 1 Synthesis of 2-(4,6-dimethoxypyrimidin-2-yloxy)-benzaldehyde (intermediate) After 2.2 g of salicylaldehyde were dissolved in 100 ml of dimethylformamide, 4.0 g of 60% sodium hydride were added little by little. The resulting mixture was stirred at room temperature for a while and, after foaming subsided, 17.5 g of <strong>[108279-89-6]2-chloro-4,6-dimethoxypyridine</strong> were added, followed by heating to 100 C. After the mixture was stirred for 3 hours at the same temperature, dimethylformamide was recovered under reduced pressure. The residue was isolated by column chromatography on a silica gel and then eluted with a 7:3 mixed solvent of n-hexane and ethyl acetate, whereby 14.8 g of the target compound, 2-(4,6-dimethoxypyrimidine-2-yloxy)benzaldehyde, were obtained as crystals (m.p.: 96-98 C.; yield: 56.9%). IR (KBr) cm-1: 2720, 1710. NMR (400 MHz, CDC;3) delta from TMS: 3.80(6H,s), 5.81(1H,s), 7.27(1H,m), 7.36(1H,m), 7.64(1H,m), 7.95(1H,m), 10.24(1H,s).
 

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