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Chemical Structure| 1095274-30-8 Chemical Structure| 1095274-30-8

Structure of 1095274-30-8

Chemical Structure| 1095274-30-8

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Product Details of [ 1095274-30-8 ]

CAS No. :1095274-30-8
Formula : C11H11ClN2O
M.W : 222.67
SMILES Code : N#CC1=CC(N2CCOCC2)=CC(Cl)=C1
MDL No. :MFCD30471064

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Application In Synthesis of [ 1095274-30-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1095274-30-8 ]

[ 1095274-30-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 110-91-8 ]
  • [ 327056-73-5 ]
  • [ 1095274-30-8 ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In dimethyl sulfoxide; at 20 - 80℃; A solution of <strong>[327056-73-5]3-chloro-5-fluorobenzonitrile</strong> (1.0 g, 6.4 mmol) in dimethyl sulfoxide (20 ml.) was stirred at room temperature under an atmosphere of argon. Potassium carbonate (1.33 g, 9.6 mmol) and then morpholine (1.12 ml_, 12.8 mmol) were added. The reaction mixture was heated at 800C under an atmosphere of argon overnight. The reaction mixture was cooled to room temperature, filtered to remove the solid potassium carbonate and then acidified to pH 5 using 1 M hydrochloric acid. No precipitate formed and so the product was applied to 2 x 10 g SCX cartridges (pre-wetted with methanol). The product did not stick to the cartridges and was washed through with the methanol. The product containing fractions were combined and concentrated under reduced pressure. The product (in dimethyl sulfoxide) was partitioned between diethyl ether and water, and a white precipitate formed. More <n="39"/>water was added to encourage precipitation. The title compound, a white solid, was collected by filtration and air dried under low vacuum.LC/MS (ES+ve): [M+H]+ at m/z 223, 225 (CH H11 CIN2O requires [M+H]+ at m/z 223, 225).
 

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