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Chemical Structure| 1086379-95-4 Chemical Structure| 1086379-95-4

Structure of 1086379-95-4

Chemical Structure| 1086379-95-4

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Product Details of [ 1086379-95-4 ]

CAS No. :1086379-95-4
Formula : C10H7NO3
M.W : 189.17
SMILES Code : O=C(O)C1=CC=NC(C2=CC=CO2)=C1
MDL No. :MFCD09414718

Safety of [ 1086379-95-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H317-H319
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 1086379-95-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1086379-95-4 ]

[ 1086379-95-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6313-54-8 ]
  • [ 374790-93-9 ]
  • [ 1086379-95-4 ]
YieldReaction ConditionsOperation in experiment
99% With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; lithium hydroxide; In 1,4-dioxane; water; at 80℃; for 0.5h;Inert atmosphere; General procedure: To a solution of 2-chloroheteroaryl compound 1 (0.50 mmol) in 1,4-dioxane (4.0 mL) were added pinacol boronate 3, 5, or 7 (0.60 mmol), Pd(OAc)2 (1.1 mg, 5.0 mumol), S-Phos (4.1 mg, 10.0 mumol), and 2 M LiOH solution (1.0 mL, 2.0 mmol) at room temperature, and the mixture was stirred for 30 min at 80 C under N2 atmosphere. The reaction was quenched by adding water, and then the mixture was extracted with ethyl acetate. The organic layer was washed with brine and dried over anhydrous magnesium sulfate. After filtration, the solvent was removed in vacuo, and the residue was purified by silica-gel column chromatography. The solvent was removed in vacuo, and the residue was triturated with Et2O to give biaryl compounds.
 

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