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Chemical Structure| 1083168-91-5 Chemical Structure| 1083168-91-5

Structure of 1083168-91-5

Chemical Structure| 1083168-91-5

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Product Details of [ 1083168-91-5 ]

CAS No. :1083168-91-5
Formula : C12H17BClNO3
M.W : 269.53
SMILES Code : CC1(C)C(C)(C)OB(C2=CN=C(OC)C(Cl)=C2)O1
MDL No. :MFCD08063054
Boiling Point : No data available
InChI Key :ZHWIZWNYOSGXSR-UHFFFAOYSA-N
Pubchem ID :53398545

Safety of [ 1083168-91-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P210-P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P370+P378-P403+P233-P403+P235-P405-P501

Application In Synthesis of [ 1083168-91-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1083168-91-5 ]

[ 1083168-91-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 848366-28-9 ]
  • [ 73183-34-3 ]
  • [ 1083168-91-5 ]
YieldReaction ConditionsOperation in experiment
78% With potassium acetate;(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 80℃; AF. 3-Chloro-2-methoxy-5-(4A5,5-tetramethyl-l,3,2-dioxaborolan-2- vDpyridine; To a dry flask was added <strong>[848366-28-9]5-bromo-3-chloro-2-methoxypyridine</strong> (0.5 g, 2.2 mmol), 4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(l,3,2-dioxaborolane) (0.70 g, 2.7 mmol), and Pd(dppf)Cl2 (82 mg, 0.10 mmol). Potassium acetate (0.6 g, 6.0 mmol) was weighed directly into the flask. The flask was then evacuated and back filled with N2. Anhydrous N,N- dimethylformamide (DMF) (13.0 mL) was added and the reaction was heated at 80 0C in an oil bath overnight. The reaction mixture was evaporated to dryness. The residue was dissolved in ethyl acetate (10 mL) and washed with water (1OmL). The organics were dried over sodium sulfate and evaporated to dryness. The resulting material was purified by silica gel chromatography (eluting with 0-100% ethyl acetate in hexanes) to yield the product (0.47 g, 78%). ESI-MS m/z calc. 269.53, found 270.3 (MW+1)+. Retention time 2.07 minutes.
 

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