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Chemical Structure| 1082065-99-3 Chemical Structure| 1082065-99-3

Structure of 1082065-99-3

Chemical Structure| 1082065-99-3

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Product Details of [ 1082065-99-3 ]

CAS No. :1082065-99-3
Formula : C8H10N2O
M.W : 150.18
SMILES Code : O=CC1=CN(CC2CC2)N=C1

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Application In Synthesis of [ 1082065-99-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1082065-99-3 ]

[ 1082065-99-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 7051-34-5 ]
  • [ 35344-95-7 ]
  • [ 1082065-99-3 ]
YieldReaction ConditionsOperation in experiment
56% Preparation 53: 1 -Cyclopropylmethyl- 1 H-<strong>[35344-95-7]pyrazole-4-carbaldehyde</strong> <n="62"/>--61-Add lH-<strong>[35344-95-7]pyrazole-4-carbaldehyde</strong> (0.200 g, 2.08 mmol) to a suspension of sodium hydride (0.092 g, 2.29 mmol) in DMF (3 mL) at 0 0C. Stir for 20 min. at 0 0C. Add a solution of l-(bromomethyl)cyclopropane (0.295 g, 2.18 mmol) in DMF (4 mL) dropwise to the reaction mixture. Stir reaction to ambient temperature for 18 hr. Quench with aqueous saturated sodium bicarbonate solution and add ethyl acetate. Separate organic layer. Extract aqueous layer twice with ethyl acetate, dry combined organics (magnesium sulfate), filter, concentrate and purify (silica gel chromatography, eluting with 0: 100 to 60:40 ethyl acetate:hexanes) to give the title preparation (175 mg, 56percent). GC-MS: m/z = 150 [M+].
 

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