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Chemical Structure| 1080522-30-0 Chemical Structure| 1080522-30-0

Structure of 1080522-30-0

Chemical Structure| 1080522-30-0

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Product Details of [ 1080522-30-0 ]

CAS No. :1080522-30-0
Formula : C8H6FN3O2
M.W : 195.15
SMILES Code : O=[N+]([O-])C1C(F)=CC=C2NC(=NC=12)C

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Application In Synthesis of [ 1080522-30-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1080522-30-0 ]

[ 1080522-30-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 118469-15-1 ]
  • [ 1080522-29-7 ]
  • [ 1080522-30-0 ]
YieldReaction ConditionsOperation in experiment
Under an N2 atmosphere, 5-fluoro-2- methyl-lH-benzo[d]imidazole (5.21 g, 34.7mmol) was dissolved in concentrated sulfuric acid (25 mL) and cooled to 0 C. Nitric acid (25 mL) was added and the reaction was stirred at 0 C for 1 h. The reaction was poured over ice and neutralized with IN NaOH. The mixture was extracted with ethyl acetate (3x). The organics were combined, dried (Na2SO4), filtered and concentrated in vacuo. The residue was triturated with 10% MeOH in dichloromethane to afford l.OOg of 5-fluoro-2-methyl-6-nitro-lH-benzo[d]imidazole after filtration. The filtrate was flash column chromatographed, eluting with 2% to 7% MeOH in dichloromethane, to afford 5-fluoro-2-methyl-4-nitro-lH-benzo[d]imidazole. LC- MS ESI (pos.) m/z: 196.0 (M+H).
 

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