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Chemical Structure| 1079402-25-7 Chemical Structure| 1079402-25-7

Structure of 1079402-25-7

Chemical Structure| 1079402-25-7

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Product Details of [ 1079402-25-7 ]

CAS No. :1079402-25-7
Formula : C8H8BF3O4
M.W : 235.95
SMILES Code : COC1=CC(B(O)O)=C(OC(F)(F)F)C=C1
MDL No. :MFCD12025981

Safety of [ 1079402-25-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H332
Precautionary Statements:P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P330-P362-P403+P233-P501

Application In Synthesis of [ 1079402-25-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1079402-25-7 ]

[ 1079402-25-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1049730-91-7 ]
  • [ 1079402-25-7 ]
YieldReaction ConditionsOperation in experiment
43% To a stirred solution of 2-Bromo-4-methoxy-1-trifluoromethoxy-benzene (Preparation 59, 19.0 g, 73.9 mmol) in anhydrous tetrahydrofuran (400 ml) was added n-butyl lithium (2.5M solution in hexanes, 44.2 ml, 110.9 mmol) while maintaining the temperature below -7O0C under an atmosphere of nitrogen. The resulting solution was stirred at -7O0C for 1 hour. Tri-/sopropyl borate (20.9 g, 110.9 mmol) was added and the mixture stirred at -7O0C for an additional 2 hours. The reaction mixture was <n="176"/>quenched with saturated ammonium chloride aqueous solution (400 ml). The resulting mixture was acidified to pH~5 by addition of hydrochloric acid (1 N aqueous solution). The layers were separated and the organic layer was washed with water (200 ml) then dried over anhydrous MgSO4 (s), filtered and evaporated in vacuo. Residue was purified by recrystallization from ethyl acetate: petroleum ether (2 ml:50 ml) to afford the title compound as a white solid (7.5 g, 43%).1HNMR (c^DMSO): 3.76 (s, 3H), 6.99 (dd, 1 H), 7.06 (d, 1 H), 7.18 (dd, 1 H), 8.36 (s, 2H).
 

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