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Chemical Structure| 107922-02-1 Chemical Structure| 107922-02-1

Structure of 107922-02-1

Chemical Structure| 107922-02-1

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Product Details of [ 107922-02-1 ]

CAS No. :107922-02-1
Formula : C14H12N2OS
M.W : 256.32
SMILES Code : CC(C1=C(C)N2C(S1)=NC(C3=CC=CC=C3)=C2)=O
MDL No. :MFCD06009746

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Application In Synthesis of [ 107922-02-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 107922-02-1 ]

[ 107922-02-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 30748-47-1 ]
  • [ 70-11-1 ]
  • [ 107922-02-1 ]
YieldReaction ConditionsOperation in experiment
93% With polyethylene glycol (PEG-400); In water; for 0.116667h;Microwave irradiation; Green chemistry; General procedure: To stirred solution of polyethylene glycol (PEG-400) (2 mL) in water (2 mL) were added 1-(2-amino-4-methylthiazol-5-yl)ethanone (2 mmol)/ethyl 2-amino-4-methylthiazole-5-carboxylate (2 mmol) and α-bromo aralkyl ketones (phenacyl bromides) (2 mmol), and the mixture was heated at 90 C or subject to microwave irradiation at 300 W, until reaction completion as indicated by TLC. After reaction completion, the reaction mixture was cooled at room temperature, and the solid product formed was collected by filtration, washed with water, and recrystallized from ethanol to give pure product. The recovered PEG with water was reused for five further cycles. 1-(3-Methyl-6-phenylimidazo[2,1-b]thiazol-2-yl)ethanone (3) Off-white solid IR mmax (KBr) cm-1: 3130.89, 1642.48, 1571.57, 1145.37, 1171.78, 1017.64. 1H NMR (400 MHz, DMSO-d6): δH (ppm) 2.55 (s, 3H, CH3), 2.80 (s, 3H, COCH3), 7.28-7.31 (t, 1H, J = 7.2 Hz, ArH), 7.43-7.40 (t, J = 7.4 Hz, 2H, ArH), 7.86-7.88 (d, J = 7.2 Hz, 2H, ArH), 8.45 (s, 1H, ArH). 13C NMR (100 MHz, DMSO): δC (ppm) 13.81, 29.36, 108.94, 125.47, 127.59, 128.69, 133.43, 135.60, 146.95, 147.44, 191.18. MS (ESI) m/z for (256.32): 257.2 (M + 1)+, 258.2 (M + 2)+. Elemental analysis: Calculated for C11H9NO2 (256.07): C 65.60%, H 4.72%, N 10.93%, S 12.51%; Found: C 65.63%, H 4.70%, N 10.92%, S 12.54%.
 

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