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Chemical Structure| 1078728-17-2 Chemical Structure| 1078728-17-2

Structure of 1078728-17-2

Chemical Structure| 1078728-17-2

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Product Details of [ 1078728-17-2 ]

CAS No. :1078728-17-2
Formula : C8H9ClN2O2
M.W : 200.62
SMILES Code : O=C(OC)C1=CC=C(N)C(N)=C1Cl
MDL No. :MFCD24642351

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Application In Synthesis of [ 1078728-17-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1078728-17-2 ]

[ 1078728-17-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 67-56-1 ]
  • [ 201230-82-2 ]
  • [ 1000573-99-8 ]
  • [ 1078728-17-2 ]
YieldReaction ConditionsOperation in experiment
6% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; In methanol; for 48h;Reflux; A mixture of <strong>[1000573-99-8]4-bromo-3-chloro-2-nitroaniline</strong> (A4) (18.9 g 75.5 mmol), Pd(dppf)Cl2 (8.27 g, 1 1.3 mmol) and EbN (22.9 g, 226.5 mmol) in MeOH (250 mL) was heated at reflux under a carbon monoxide atmosphere for 48 h. The mixture was poured into water (500 mL) and extracted with EtOAc (250 mL c 3). The combined organic extracts were washed with brine (250 mL), dried over Na2SC>4, filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatography (Pet. Ether/EtOAc = 5: 1 to 2: 1) to give the title compound (1.0 g, 6%) as a yellow solid. 1 H NMR (400 MHz, DMSO-de) d 7.08 (d, J = 8.4 Hz, 1 H), 6.48 (d, J = 8.4 Hz, 1 H), 5.58 (s, 2H), 4.89 (s, 2H), 3.72 (s, 3H).
 

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