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Chemical Structure| 1073973-07-5 Chemical Structure| 1073973-07-5

Structure of 1073973-07-5

Chemical Structure| 1073973-07-5

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Product Details of [ 1073973-07-5 ]

CAS No. :1073973-07-5
Formula : C15H17NO3
M.W : 259.30
SMILES Code : O=C1N(C2CCC(OC)CC2)C(C3=C1C=CC=C3)=O
MDL No. :MFCD28405049

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1073973-07-5 ]

[ 1073973-07-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 104618-31-7 ]
  • [ 74-88-4 ]
  • [ 1073973-07-5 ]
YieldReaction ConditionsOperation in experiment
48.3% To a solution of 1.534 g (6.26 mmol) of 2-(4-Hydroxy-cyclohexyl)-isoindole-1,3-dione in 60 mL THF was added 0.553 g (13.8) NaH (60% in oil) and reaction mixture stirred under N2 until gas formation ceased. The mixture was cooled to 0 C. and 3.56 g (25.1 mmol) MeI was added and the reaction was stirred at 25 C. for 24 hours. The mixture was then poured into 180 mL sat. NH4Cl(aq) and extracted 3 times with DCM. The organic layers were dried over Na2SO4, concentrated and then purified via chromatography (50% EtOAc/Hex) to give 908 mg of 2-(4-Methoxy-cyclohexyl)-isoindole-1,3-dione (48.3% yield, LCMS (m/z): M+H=301.1). That was dissolved in 40 mL EtOH and 324 mg (8.76 mmol) Hydrazine was added. The reaction mixture was stirred at 65 C. for 3 hours. By the end of the 3 hours the solution was mostly white solid and a little liquid. The reaction was filtered and washed 3 times with 30 mL MeOH and concentrated to give 450 mg of crude product of 4-Methoxy-cyclohexylamine (ca. 100% yield). LCMS (m/z): M+H=130.2.
 

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