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Chemical Structure| 1073160-19-6 Chemical Structure| 1073160-19-6

Structure of 1073160-19-6

Chemical Structure| 1073160-19-6

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Product Details of [ 1073160-19-6 ]

CAS No. :1073160-19-6
Formula : C13H10ClF3N4O
M.W : 330.69
SMILES Code : O=C(NC)C1=CC=C(NC2=NC=C(C(F)(F)F)C(Cl)=N2)C=C1
MDL No. :MFCD28972477
InChI Key :IJEBTSOYCUVHFB-UHFFFAOYSA-N
Pubchem ID :57584546

Safety of [ 1073160-19-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 1073160-19-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1073160-19-6 ]

[ 1073160-19-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6274-22-2 ]
  • [ 3932-97-6 ]
  • [ 1073160-19-6 ]
YieldReaction ConditionsOperation in experiment
40% Preparation of 4-(4-chloro-5-(trifluoromethyl)pyrimidin-2-ylamino)-N-methylbenzamide (B20) ; A solution of 2,4-dichloro-5-trifluoromethyl-pyrimidine (8.63 mmol) in 1:1 t-BuOH/DCE (10 mL) was cooled to 5 C., treated with solid ZnBr2 (22.5 mmol), and stirred at 5 C. for 30 minutes. The resultant solution was maintained at 5 C. and treated first with solid <strong>[6274-22-2]4-amino-N-methyl-benzamide</strong> (7.5 mmol) followed by TEA (16.5 mmol). The resultant white mixture was allowed to warm 25 C., and it was mixed at 25 C. for 20 hours. The mixture was adsorbed onto silica gel, and the fraction eluting 0-10% methanol/DCM was collected and concentrated. The resultant residue was triturated with water and filtered to provide B20. Yield: 3.0 mmol, 40%. LCMS 2.3 min, MZ+=331.1 1H NMR (500 MHz, d6-DMSO) delta ppm 10.89 (s, 1H), 8.87 (s, 1H), 8.34 (d, J=4.67 Hz, 1H), 7.73-7.89 (m, 3H), 2.78 (d, J=4.67 Hz, 3H).
 

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