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Chemical Structure| 1063697-17-5 Chemical Structure| 1063697-17-5

Structure of 1063697-17-5

Chemical Structure| 1063697-17-5

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Product Details of [ 1063697-17-5 ]

CAS No. :1063697-17-5
Formula : C6H4F3NO
M.W : 163.10
SMILES Code : OC1=CC=CN=C1C(F)(F)F
MDL No. :MFCD13185667

Safety of [ 1063697-17-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P305+P351+P338

Application In Synthesis of [ 1063697-17-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1063697-17-5 ]

[ 1063697-17-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 40263-57-8 ]
  • [ 1514-87-0 ]
  • [ 1063697-17-5 ]
YieldReaction ConditionsOperation in experiment
With potassium fluoride; copper(l) iodide; In 1-methyl-pyrrolidin-2-one; at 120℃;Inert atmosphere; NMP (145 mL) is degassed 30 min with Ar and is then heated to 80 C. KF (7.62 g, 131 mmol), Cul (I) (24.99 g, 131 mmol) and <strong>[40263-57-8]2-iodopyridin-3-ol</strong> (29 g, 131 mmol) are added in one portion, followed by methyl 2-chloro-2,2-difluoroacetate (55.4 mL, 525 mmol).The resulting mixture is heated at 120 C under N2 for 3 nights. The mixture is allowed to cool to RT and is then poured gently into a slowly stirring mixture of 50% concentrated NaCI (1 L) solution and Et20 (4L). The organic layer is decanted carefully and the aqueous layer is extracted with Et20 (3x). The combined organic layers are concentrated, washed with brine (4x), dried with MgS04, filtered and concentrated. Flash chromatography on silica (DCM:MeOH 1.2%-10) then with (i- Pr20:EtOAc 9:1 ) follwed by trituration in heptane provides 12a1.
 

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