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Chemical Structure| 1054629-56-9 Chemical Structure| 1054629-56-9

Structure of 1054629-56-9

Chemical Structure| 1054629-56-9

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Product Details of [ 1054629-56-9 ]

CAS No. :1054629-56-9
Formula : C14H11FN2O2
M.W : 258.25
SMILES Code : NC1=NC(F)=C(C2=CC3=CC(OC)=CC=C3O2)C=C1

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Application In Synthesis of [ 1054629-56-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1054629-56-9 ]

[ 1054629-56-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 551001-79-7 ]
  • [ 944401-65-4 ]
  • [ 1054629-56-9 ]
YieldReaction ConditionsOperation in experiment
With triethylamine;bis-triphenylphosphine-palladium(II) chloride; In ethanol; at 140℃; for 0.25h;Microwave; 5-Methoxybenzofuran boronic acid (230 mg, 1.20 mmol), <strong>[944401-65-4]5-bromo-6-fluoro-pyridin-2-ylamine</strong> (191 mg, 1.00 mmol), Pd(PPh3)2Cl2 (16.8 mg, 0.024 mmol) and Et3N (317 muL, 2.27 mmol) were mixed in EtOH (10 mL) in a microwave vial. The reaction mixture was stirred at 140 C. for 15 minutes in a microwave reactor. The volatiles were then removed under reduced pressure, the residue was suspended in water and the product was extracted with ethyl acetate. The organic layer was dried over Na2SO4, filtered and concentrated in vacuo. Purification of the crude product by flash column chromatography using 25% ethyl acetate in hexane gave 6-fluoro-5-(5-methoxy-benzofuran-2-yl)-pyridin-2-ylamine (130 mg) as an off-white solid. 1H NMR (400 MHz, CHLOROFORM-d) delta: 8.05-8.21 (m, 1H) 7.36 (d, J=8.59 Hz, 1H) 7.03 (d, J=1.95 Hz, 1H) 6.97 (d, J=3.12 Hz, 1H) 6.86 (dd, J=8.78, 2.54 Hz, 1H) 6.45 (d, J=6.63 Hz, 1H) 4.66 (br. s., 2H) 3.86 (s, 3H)
 

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