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Chemical Structure| 105118-15-8 Chemical Structure| 105118-15-8

Structure of 105118-15-8

Chemical Structure| 105118-15-8

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Product Details of [ 105118-15-8 ]

CAS No. :105118-15-8
Formula : C9H10O4
M.W : 182.17
SMILES Code : C[C@H](OC1=CC=C(O)C=C1)C(O)=O

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Application In Synthesis of [ 105118-15-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 105118-15-8 ]

[ 105118-15-8 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 940-31-8 ]
  • [ 105118-15-8 ]
  • [ 94050-90-5 ]
  • 2
  • [ 94050-90-5 ]
  • [ 105118-15-8 ]
  • [ 94050-90-5 ]
  • 3
  • [ 111842-06-9 ]
  • [ 105118-15-8 ]
  • [ 94050-90-5 ]
YieldReaction ConditionsOperation in experiment
95% With water; sodium hydroxide; In ethyl acetate; at 20℃;pH 9; The compound (11.9 g, 50 mmol) was dissolved in 100 ml of ethyl acetate and stirred at room temperature, 10% dropwise.Aqueous NaOH solution until the pH of the solution is 9, fully stirred, the reaction is complete, the solution is allowed to stand, and the lower aqueous solution is cooled in an ice bath.Add hydrochloric acid until the pH is 1, stir for 2 hours, precipitate the solid and filter and dry to obtain the compound.(R)-(+)-2-p-hydroxyphenoxypropionic acid 8.64 g, yield 95%, R/S 92/8.
  • 4
  • C13H16O5 [ No CAS ]
  • [ 105118-15-8 ]
  • [ 94050-90-5 ]
YieldReaction ConditionsOperation in experiment
96% With water; sodium hydroxide; In ethyl acetate; at 20℃;pH 9; The compound (12.6 g, 50 mmol) was dissolved in 100 ml of ethyl acetate, and stirred at room temperature, 10% aqueous NaOH solution was added dropwise until the pH of the solution was 9, thoroughly stirred, the reaction was completed, and the mixture was allowed to stand for separation, and the lower aqueous solution was cooled in an ice bath. Hydrochloric acid was added dropwise until the pH was 1, and the mixture was stirred for 2 hours, and the precipitated solid was filtered and dried to give the compound (R)-(+)-2-p-hydroxyphenoxypropionic acid (8.73 g), yield 96%, R/S. It is 93/7.
 

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