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Chemical Structure| 1048108-06-0 Chemical Structure| 1048108-06-0

Structure of 1048108-06-0

Chemical Structure| 1048108-06-0

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Product Details of [ 1048108-06-0 ]

CAS No. :1048108-06-0
Formula : C10H12BrNO2
M.W : 258.11
SMILES Code : O=C(N(OC)C)C1=CC(C)=CC=C1Br

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Application In Synthesis of [ 1048108-06-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1048108-06-0 ]

[ 1048108-06-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 6967-82-4 ]
  • [ 6638-79-5 ]
  • [ 1048108-06-0 ]
YieldReaction ConditionsOperation in experiment
55% With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20℃; for 60h; To a solution of <strong>[6967-82-4]2-bromo-5-methylbenzoic acid</strong> (1000.0 mg, 4.65 mmol) in DMF (100 mL) were added N,O-dimethylhydroxylamine hydrochloride (454 mg, 4.65 mmol), EDC (891 mg, 4.65 mmol), and HOBT (628 mg, 4.65 mmol). The reaction mixture was stirred at rt for 2.5 days. The reaction mixture was diluted with water and extracted with EtOAc. The combined organic phases were dried over Na2SO4, filtered and concentrated in vacuum. The residue was purified by silica gel chromatography to give 2-bromo-N-methoxy-N,5-dimethylbenzamide (656 mg, 55%) as a colorless oil. LC-MS (M+H)+=258.21.
  • 2
  • [ 6967-82-4 ]
  • [ 1048108-06-0 ]
 

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