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Chemical Structure| 1036027-56-1 Chemical Structure| 1036027-56-1

Structure of 1036027-56-1

Chemical Structure| 1036027-56-1

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Product Details of [ 1036027-56-1 ]

CAS No. :1036027-56-1
Formula : C15H11F3N2O2S
M.W : 340.32
SMILES Code : FC(C1=CN=C(N(S(=O)(C2=CC=C(C)C=C2)=O)C=C3)C3=C1)(F)F

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Application In Synthesis of [ 1036027-56-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1036027-56-1 ]

[ 1036027-56-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1036027-54-9 ]
  • [ 98-59-9 ]
  • [ 1036027-56-1 ]
YieldReaction ConditionsOperation in experiment
92% With sodium hydride; In tetrahydrofuran; at 20 - 40℃; [0187] To a stirred solution of sodium hydride (6.2g, 156 mmol, 60% dispersion), tosyl chloride ( 27g, 141.8 mmol), in anhydrous THF (20OmL) under a nitrogen atmosphere was added a solution of 5-trifluoromethyl-lH-pyrrolo[2,3-b]pyridine (26.38g, 141.8mmol) inTHF (15OmL) dropwise at a rate which maintained the internal temperature of the reaction <n="61"/>below 40 0C. The reaction mixture was stirred overnight at room temperature and analysis by LCMS showed no starting material remained after this time. The reaction mixture was concentrated to remove most of THF and diluted with DCM and water. The organic layer was separated and the aqueous layer further extracted with DCM. The organic layers are combined and washed with brine, dried over magnesium sulphate and concentrated to a volume which was appropriate to load onto the top of a silica plug (30OmL) pre-wet with DCM, and the silica was washed with 2.5L DCM. The filtrate was concentrated to give the product as a slightly brown solid (44.1g, 92% yield).
 

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