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Chemical Structure| 1035490-58-4 Chemical Structure| 1035490-58-4

Structure of 1035490-58-4

Chemical Structure| 1035490-58-4

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Product Details of [ 1035490-58-4 ]

CAS No. :1035490-58-4
Formula : C13H18FNO3
M.W : 255.29
SMILES Code : CC(C)(C)OC(N[C@@H](C1=CC(F)=CC=C1)CO)=O
MDL No. :MFCD29076508
InChI Key :PXLWDYOUWTYABH-LLVKDONJSA-N
Pubchem ID :66763747

Safety of [ 1035490-58-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 1035490-58-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1035490-58-4 ]

[ 1035490-58-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 24424-99-5 ]
  • [ 1240480-36-7 ]
  • [ 1035490-58-4 ]
YieldReaction ConditionsOperation in experiment
Boc-protected amino alcohol (A)A mixture of the amino alcohol hydrochloride (192.22 mmol) and di-f-butyl dicarbonate (262.63 mmol, 1.37 eq) was suspended in f-BuOH (250 mL, 6.25 volumes) and then treated with aqueous 2 N NaOH (120 mL, 240 mmol). The contents were warmed to 75 C (immediate effervescence was observed) for 4 h. The internal temp was then reduced to 50 C, and the contents were added to water (2 L) with vigorous stirring. After 15 min, a pure, white solid (A) precipitated, and the contents were cooled to 5 C, prior to filtration. The collected solid was washed with water (0.5 L) and dried under vacuum at 35 C for 18 h (90-99% yield).Example 1 was prepared following the general synthesis of A-E starting with (S)-2- amino-2-(3-fluoro-phenyl)-ethanol. LC-MS [366 (M+1 )]
 

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