Home Cart Sign in  
Chemical Structure| 1027706-07-5 Chemical Structure| 1027706-07-5

Structure of 1027706-07-5

Chemical Structure| 1027706-07-5

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 1027706-07-5 ]

CAS No. :1027706-07-5
Formula : C10H9BN2O3S
M.W : 248.07
SMILES Code : O=C(C1=CSC=N1)NC(C=C2)=CC=C2B(O)O

Safety of [ 1027706-07-5 ]

Application In Synthesis of [ 1027706-07-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1027706-07-5 ]

[ 1027706-07-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 3973-08-8 ]
  • [ 89415-43-0 ]
  • [ 1027706-07-5 ]
YieldReaction ConditionsOperation in experiment
To 1 ,3-thiazole-4-carboxylic acid (2.5 g) was added dry DMF (68 ml_), DIPEA (6.67 ml.) and HATU (13.1 g). The reaction was stirred at room temperature for 1 h under nitrogen. (4- Aminophenyl)boronic acid (5.1 g) was added and the reaction was stirred for 24 h, then partitioned between EtOAc and saturated sodium bicarbonate solution. The organic phases were washed further with saturated sodium bicarbonate solution, water, 2N HCI (x 2) and brine. The organic phases were passed through a hydrophobic frit and evaporated in vacuo. The crude material was purified by ISCO Companion silica chromatography, eluting with a gradient 0-100% EtOAc in cyclohexane to give the title compound. MS calcd for (Ci0H9BN2O3S + H)+: 331 MS found (electrospray): (M+H)+ = 331
  • 2
  • [ 3973-08-8 ]
  • [ 214360-73-3 ]
  • [ 1027706-07-5 ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; HATU; In water; N,N-dimethyl-formamide; for 0.75h; To a solution of 4-am inophenylboronic acid pinacol ester A4a (500 mg, 2.3 mmol, Oakwood) in DMF (5 mL) is added 1,3-thiazole-4-carboxylic acid Ala (383.1 mg, 3.0 mmol, Combi Blocks), DIPEA (993.8 iL, 5.7 mmol) and HATU (1 .2 g, 3.2 mmol). The reaction mixture is stirred for 45 mm, and then water (15 mL) is added and the suspension is stirred overnight. The precipitate is filtered and rinsed with water (10 mL) and DCM (10 mL). The residue is dried under high vacuum and nitrogen flow for 15 mm to afford A4b which is used as such in subsequent steps.
 

Historical Records

Categories