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Chemical Structure| 10250-61-0

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Product Details of [ 10250-61-0 ]

CAS No. :10250-61-0
Formula : C7H10N2O2
M.W : 154.17
SMILES Code : O=C(C1=NN(C)C(C)=C1)OC
MDL No. :MFCD06661312
InChI Key :WOBRRDCECRRRGS-UHFFFAOYSA-N
Pubchem ID :2755339

Safety of [ 10250-61-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 10250-61-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 10250-61-0 ]

[ 10250-61-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 4027-57-0 ]
  • [ 74-88-4 ]
  • [ 10250-61-0 ]
  • [ 10250-59-6 ]
YieldReaction ConditionsOperation in experiment
Example 14 alpha-Cyano-p-fluoro-3-(1,5-dimethyl-3-pyrazolyl)-beta-oxopropionanilide A solution of 2.6 g of beta-(1,5-dimethyl-3-pyrazolyl)-beta-oxopropionitrile and 1.8 g of triethylamine in 20 ml of dimethoxyethane is treated with 2.4 g of p -fluorophenylisocyanate. After standing overnight the crystalline, crude mixture is treated with dilute HCl and the product collected, washed with water, dried, and triturated with methanol and ethyl acetate to give colorless crystals, m.p. 235-240. After recrystallization from ethyl acetate, the compound melts at 239-241. The starting material is prepared as follows: 58 g of acetone and 146 g of ethyl oxalate are condensed with a solution of 26 g of sodium in 500 ml of reagent methanol. The obtained sodium salt of methyl 2,4-dioxovalerate is washed with ethanol and dried, m.p. 260-1 (dec.). Following the method of v. Auwers and Hollmann, Ber. 59 , 605, 1282 (1926), an aqueous solution (100 ml) of 20 g of the sodium salt of methyl 2,4-dioxovalerate is treated with a solution of 6.4 ml of methylhydrazine in aqueous sulfuric acid prepared from 12.5 g of cold conc. H2SO4 and 20 g of ice. After stirring for 1 hr, the solution is carefully made alkaline with sodium hydroxide solution. The products are extracted with diethyl ether, and the etheral solution dried with sodium sulfate and evaporated. On trituration with cold diethyl ether, crystals of methyl 1,5-dimethyl-3-pyrazolylcarboxylate, m.p. 72-5, are obtained. Recrystallization from diethyl ether raises the m.p. to 75-7. The etheral filtrate from the trituration is evaporated, and the residual oil distilled in vacuo , affording methyl 1,3-dimethyl-5-pyrazolylcarboxylate , b.p. 100-102/12 mbar.
 

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