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Chemical Structure| 1015782-45-2 Chemical Structure| 1015782-45-2

Structure of 1015782-45-2

Chemical Structure| 1015782-45-2

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Product Details of [ 1015782-45-2 ]

CAS No. :1015782-45-2
Formula : C7H9ClN2O
M.W : 172.61
SMILES Code : O=C(Cl)CN1N=C(C)C=C1C
MDL No. :MFCD03421571

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Application In Synthesis of [ 1015782-45-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1015782-45-2 ]

[ 1015782-45-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 16034-49-4 ]
  • [ 1015782-45-2 ]
YieldReaction ConditionsOperation in experiment
With oxalyl dichloride;N,N-dimethyl-formamide; In dichloromethane; at -5 - 20℃; (3,5-Dimethyl-lH-pyrazol-l-yl)acetic acid (21 mg, 0.125 mmol) is dissolved in dichloromethane (1 mL) and cooled to -5 0C. To this is added oxalyl chloride solution (2 M in dichloromethane, 0.063 mL, 0.125 mmol), followed by 0.02 mL DMF. The mixture is stirred for 2 h warming to room temperature. To the acid chloride solution is then added a solution of the above piperazine intermediate (30 mg, 0.119 mmol) and Hunig's base (0.104 mL, 0.595 mmol) in dichloromethane (1 mL) and the reaction is stirred at ambient temp for 20 h. The reaction is concentrated in vacuo at 40 0C to a residue. The residue is diluted with DMF (2 mL), water (1 mL) and TFA (0.2 mL) and purified by reverse-phase preparative HPLC (10-100% CH3CN/H2O) to give 21 mg of the title compound.
 

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