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Chemical Structure| 100953-23-9 Chemical Structure| 100953-23-9

Structure of 100953-23-9

Chemical Structure| 100953-23-9

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Product Details of [ 100953-23-9 ]

CAS No. :100953-23-9
Formula : C12H10O4
M.W : 218.21
SMILES Code : O=C1CC2C(OC(C2)=O)(C3=CC=CC=C3)O1

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Application In Synthesis of [ 100953-23-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 100953-23-9 ]

[ 100953-23-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 99-14-9 ]
  • [ 100953-23-9 ]
  • 2
  • [ 99-14-9 ]
  • [ 93-97-0 ]
  • [ 100953-23-9 ]
YieldReaction ConditionsOperation in experiment
78% With pyridine; In m-xylene; at 140℃; General procedure: Into a one-necked 25 mL flask, tricarballylic acid (518 mg, 2.95 mmol, 1.0 equiv) and the appropriate anhydride (8.83 mmol, 3 equiv) were suspended in m-xylene (5 mL, 0.6 M). Pyridine was added (47 muL, 0.59 mmol, 0.2 equiv) in one portion, then the mixture was heated to 140 C and stirred until the completion of the reaction was indicated by GC-MS (5-21 h). After cooling to r.t., CH2Cl2 (100 mL) was added and the mixture was passed through a short pad of Celite to remove insoluble side-products. The solution was washed with saturated Na2CO3 solution (2 10 mL) then with brine (10 mL). The organic phase was dried over Na2SO4, filtered, and evaporated to dryness. Purification by flash chromatography (hexanes/EtOAc) afforded the pure Fittig lactone.
 

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