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Chemical Structure| 1006376-63-1 Chemical Structure| 1006376-63-1

Structure of 1006376-63-1

Chemical Structure| 1006376-63-1

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Product Details of [ 1006376-63-1 ]

CAS No. :1006376-63-1
Formula : C8H6F2O
M.W : 156.13
SMILES Code : FC1=CC=C([C@@H]2OC2)C=C1F
MDL No. :MFCD23142999

Safety of [ 1006376-63-1 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225
Precautionary Statements:P501-P240-P210-P233-P243-P241-P242-P280-P370+P378-P303+P361+P353-P403+P235
Class:3
UN#:1993
Packing Group:

Application In Synthesis of [ 1006376-63-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1006376-63-1 ]

[ 1006376-63-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 405-03-8 ]
  • [ 1006376-63-1 ]
YieldReaction ConditionsOperation in experiment
95.5% Under nitrogen protection,7 g (20 mmol) of (S) -dinaphthol phosphate and 14 g (100 mmol) of <strong>[405-03-8]3,4-difluorostyrene</strong> were mixed in tetrahydrofuran for 10 to 15 min,Hydrogen peroxide was then added dropwise maintaining 10 deg.] C 142.0g (30%, 200mmol),The reaction was maintained at a temperature for 4 hours,Reaction is completed,Water was added to the reaction solution,Layered,Organic layer washed,Concentrated under reduced pressure,Petroleum ether recrystallization To give 14.9 g of (2S) -2- (3,4-difluorophenyl) oxirane, a yield of 95.5% and an ee value of 98.92%.
  • 2
  • [ 405-03-8 ]
  • [ 1006376-63-1 ]
  • 2-(3,4-difluorophenyl) ethylene oxide [ No CAS ]
YieldReaction ConditionsOperation in experiment
N-methylmorpholine N-oxide (16.2 g, 2.3 equiv., 138 mmol), catalyst 1 (0.88 g, 0.02 equiv., 1.2 mmol),Catalyst 3 (0.8 g, 0.02 equiv., 1.2 mmol) dichloromethane 80 mL and ethanol 30 mL were added to a 250 mL three-neck round bottom flask.Add <strong>[405-03-8]3,4-difluorostyrene</strong> (8.4 g, 1.0 equiv., 60.0 mmol) and stir at room temperature for 15 minutes.Then, it was cooled to -45 C, and 85% of m-chloroperoxybenzoic acid (19.5 g, 1.6 equiv., 96.0 mmol) dissolved in 45 mL of ethanol was slowly added dropwise, and the addition was completed in about half an hour, and the mixture was stirred for 4 hours with 1.0. The pH of the sodium/mol sodium hydroxide solution is adjusted to about 9,After extracting with 100 mL of dichloromethane and 15 mL of water, the organic layer was dried over anhydrous sodium sulfate for 3 hours.Recovery of the solvent under reduced pressure to give a viscous orange was purified by column chromatography (eluent: petroleum ether / ethyl acetate = 20/1) to give a yellow oil ((S) -2- (3,4- difluorophenyl yl) oxirane) 7.9g,The yield was 84% and the e.e. value was 87%
 

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