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Chemical Structure| 10055-40-0 Chemical Structure| 10055-40-0

Structure of 10055-40-0

Chemical Structure| 10055-40-0

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Product Details of [ 10055-40-0 ]

CAS No. :10055-40-0
Formula : C13H10FNO
M.W : 215.22
SMILES Code : O=C(C1=CC=C(N)C=C1)C2=CC=C(F)C=C2
MDL No. :MFCD00498555

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Application In Synthesis of [ 10055-40-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 10055-40-0 ]

[ 10055-40-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2195-47-3 ]
  • [ 10055-40-0 ]
YieldReaction ConditionsOperation in experiment
92% With iron; ammonium chloride; In Isopropyl acetate; at 80℃; for 3h; To a stirred solution of compound IS (5.0 g, 20.0 mmol) in IPA (30 mL), iron powder (5.7 g, 102.0 mmol) and NH4C1 (5.5 g, 102.0 mmol) in water (30 mL) were added and the reaction was stirred at 80C for 3 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was filtered and the filtrate was concentrated under reduced pressure. The residue was diluted with water and the product was extracted with EtOAc. The combined organic layer was washed with brine, dried over anhydrous Na2S04 and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using 10% EtOAc/hexane to afford IT (4.0 g, 92.0%) as a light yellow semisolid. 1H NMR (400 MHz, DMSO-d6): _ 7.69 - 7.65 (m, 2H), 7.51 (d, 7 = 8.8 Hz, 2H), 7.34- 7.30 (m, 2H), 6.60 (d, 7 = 8.8 Hz, 2H), 6.17 (s, 2H).
 

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