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Chemical Structure| 76939-46-3 Chemical Structure| 76939-46-3

Structure of 76939-46-3

Chemical Structure| 76939-46-3

8-Bromoadenosine 3',5'-cyclic monophosphate sodium salt

CAS No.: 76939-46-3

8-Bromo-cAMP is a cell permeable analog of cAMP that activates cyclic-AMP-dependent protein kinase with a Ka value of 0.05 μM and aPKA activator.

Synonyms: 8-Bromo-cAMP sodium salt; 8-Br-Camp sodium salt; 8 Br cAMP Na

4.5 *For Research Use Only !

Cat. No.: A551904 Purity: 98%

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Product Details of 8-Bromoadenosine 3',5'-cyclic monophosphate sodium salt

CAS No. :76939-46-3
Formula : C10H10BrN5NaO6P
M.W : 430.08
SMILES Code : NC1=C(N=C(Br)N2[C@@H]3O[C@@](COP(O4)([O-])=O)([H])[C@]4([H])[C@H]3O)C2=NC=N1.[Na+]
Synonyms :
8-Bromo-cAMP sodium salt; 8-Br-Camp sodium salt; 8 Br cAMP Na
MDL No. :MFCD00005844
InChI Key :DMRMZQATXPQOTP-GWTDSMLYSA-M
Pubchem ID :23702958

Safety of 8-Bromoadenosine 3',5'-cyclic monophosphate sodium salt

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of 8-Bromoadenosine 3',5'-cyclic monophosphate sodium salt

Hedgehog

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Nonpregnant uterine artery endothelial cells (NP-UAECs) 1 μM and 1 mM 0 to 60 minutes or 12 hours 8-Br-cAMP did not significantly increase Cx43 S365 signal in NP-UAECs. PMC5507815
Pregnant uterine artery endothelial cells (P-UAECs) 1 μM and 1 mM 0 to 60 minutes or 12 hours 8-Br-cAMP significantly increased nonphosphorylated Cx43 S365 signal and total Cx43 phosphorylation, but not S368 phosphorylation. PMC5507815
Human umbilical vein endothelial cells (HUVECs) 200 μM 1 hour Mimicked the effect of caffeine in inducing AMPK phosphorylation and enhanced endothelial cell migration PMC8632980
Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) 0.5 mM 21 days 8-Br-cAMP upregulated vimentin and CD13 and downregulated CK and CD9, promoting the differentiation of WJ-MSCs into ESC-like cells. PMC5667478
Human endometrial stromal (hES) cells 0.5 mM 2-4 days Investigate the differential regulation of mTORC1 and mTORC2 during 8-Br-cAMP-induced decidualization. Results showed increased mTORC1 activity and decreased mTORC2 activity, leading to reduced Akt phosphorylation and activation of FOXO1, promoting the expression of decidualization markers PRL and IGFBP1. PMC6206090
Human esophageal cancer cell line Eca-109 2×10-5 mol/L 24 hours To investigate the effects of 8-Br-cAMP on differentiation and apoptosis of Eca-109 cells. Results showed that the signals of wt p53 and iNOS were markedly stronger, while the signals of c-myc and EGFR were obviously weaker in E1 group (24-hour treatment). PMC4355801
JEG-3 cells 250 µM 36 hours Induced trophoblastic differentiation and upregulated LGALS16 and CGB3/5 gene expression PMC8699332
Human esophageal cancer cell line Eca-109 2×10-5 mol/L 48 hours To investigate the effects of 8-Br-cAMP on differentiation and apoptosis of Eca-109 cells. Results showed that the signals of wt p53, iNOS, p38 kinase, and caspase-3 were significantly stronger, whereas the signals of bcl-2, c-myc, and Fas/FasL were markedly weaker in E2 group (48-hour treatment). PMC4355801
BeWo cells 250 µM 48 hours Induced trophoblastic differentiation and upregulated LGALS16 and CGB3/5 gene expression PMC8699332
Rat heart cells 10 μM 5 minutes To evaluate the protective effects of 8-Br on the heart, results showed that 8-Br significantly reduced ventricular arrhythmias, improved hemodynamic function, and reduced infarct size PMC8155893
Differentiated HL-60 neutrophil-like cells (dHL-60) 10 µM 7 hours Inhibited NETosis induced by PMA or rabbit anti-B19V-VP1u IgG PMC11432092
Canine ventricular myocytes 250 μM To investigate the effect of 8-Br-cAMP on IKr and IKs, results showed that 8-Br-cAMP significantly increased the current amplitudes of IKr and IKs PMC3042199

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