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CAS No. : | 74877-07-9 |
Formula : | C8H9Cl2N |
M.W : | 190.07 |
SMILES Code : | CC(N)C1=CC=C(Cl)C(Cl)=C1 |
MDL No. : | MFCD01123279 |
Boiling Point : | No data available |
InChI Key : | UJUFOUVXOUYYRG-UHFFFAOYSA-N |
Pubchem ID : | 3159242 |
GHS Pictogram: | ![]() |
Signal Word: | Danger |
Hazard Statements: | H314 |
Precautionary Statements: | P280-P305+P351+P338-P310 |
Class: | 8 |
UN#: | 2735 |
Packing Group: | Ⅲ |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
6.4 g of a 27% aqueous sodium hydroxide solution was added to the aqueous layer deter extracted with toluene, the aqueous solution was extracted with 50 g of toluene, and the toluene was distilled off to obtain 4 g of 1-(3',4'-dichlorophenyl)ethylamine. A portion of the latter was taken out and analyzed by high performance liquid column chromatography using the optically active column. The optical isomer ratio was S/R=49.2/50.8. | ||
Comparative Example 12 0.6 g of potassium t-butoxide was added to a mixture of 2 g of (R)-1-(3',4'-dichlorophenyI)ethylamine used in Example 39 and 6 g of dimethyl sulfoxide at 80 C., and the mixture was continued to stir at the same temperature for 6 hours. Then 10 g of toluene was added thereto, and the reaction mixture was washed twice with 10 g of saturated sodium chloride solution, dried over anhydrous sodium sulfate, and the toluene was distilled off to obtain 2.1 g of brown oil. Purification by distillation afforded 0.6 g of 1-(3',4'-dichlorophenyl)ethylamine. A portion thereof was taken out and optical isomer ratio was analyzed by high performance liquid chromatography with the optically active column. The optical isomer ratio S/R=22.9/77.1. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
60% | In ammonium formate; | PREPARATION EXAMPLE 4 Preparation of Benzylamine Derivative Commercially available 3,4-dichloroacetophenone in the amount of 33.3 grams (176 millimoles) was mixed with 35.4 grams (562 millimoles) of ammonium formate, and the resulting mixture was stirred at 180 C. for 5 hours. Thereafter the same procedure as in preparation example 1 was performed to yield a free oil layer. This oil layer was separated and subjected to vacuum distillation under conditions of 88.5 C. and 0.3 mmHg to yield 20.1 grams (106 millimoles) of a benzylamine derivative, 3,4-dichloro-α-methylbenzylamine (yield, 60%). |
b.) N-[l-(3,4-Dichlorophenyl)ethyl]-propan-l,3-diamine; b/1.) [1 -(3 ,4-dichloroρhenyl)ethyl] amine; To the solution of 5 g (26.45 mmol) 3,4-dichloro-acetophenon in 66 ml methanol 25.4 g (0.33 mol) ammonium acetate and 1.2 g (19.1 mmol) sodium-cyano-borohydride are added under stirring at room temperature and stirring is continued for 24 hours. The reaction mixture is poured to 15 ml 5N hydrochloric acid solution under ice- water cooling then extracted with 2x15 ml ether. The acidic solution is alkalinized to pH 9, the aqueous solution is extracted with 3x20 ml dichloromethane, dried over sodium sulfate, filtered off, evaporated in vacuum. Thus 2.7 g title compound is obtained in the form of an oil. LC-MS[MH+]= 190 (C8H9Cl2N 190.072). | ||
With ammonium acetate; sodium cyanoborohydride; In ethanol; at 120℃; for 0.166667h;Microwave irradiation; | In a microwave vial charged with 1-(3,4-dichlorophenyl)ethanone (0.5 g, 2.65 mmol, 1.0 eq.), Ammonium acetate (2.05 g, 26.59 mmol, 10.0 eq.) and sodium cyanoborohydride (0.116 g, 1.85 mmol, 0.7 eq.), in EtOH (10 mL). The resulting mixture was heated at 120 C. for 10 min. Following this, the reaction mixture was allowed to cool to RT, basified with 6N NaOH until pH˜10 and extracted with EtOAc (3*15 mL). The combined organic layers were washed with brine (25 mL), dried over Na2SO4 and concentrated under reduced pressure to get the title compound as half white solid which was carried forward without any further purification (0.4 g crude). LCMS: 189.9 [M+1]+ |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With N-[3-(diethylamino)propyl]-N'-ethylcarbodiimide hydrochloride; In DMF (N,N-dimethyl-formamide); at 20℃; for 3h; | 0.30 g of 3-{3-methoxy-4- (2-propynyloxy)phenyl}propionic acid, 0.24 g of 1-(3,4-dichlorophenyl)ethylamine, 0.26 g of WSC and 10 ml of dimethylformamide were mixed, and stirred at room temperature for 3 hours. Then water was added to the reaction mixture and extracted with ethyl acetate. The organic layer was washed successively with 5 % hydrochloric acid, saturated aqueous solution of sodium bicarbonate and saturated aqueous solution of sodium chloride, dried by magnesium sulfate, and concentrated under reduced pressure. The residue was washed by hexane to obtain 0.25 g of N-{1-(3,4-dichlorophenyl)ethyl}-3-{3-methoxy-4-(2-propynylo xy) phenyl}propanamide (referred as the compound of the present invention 94 hereinafter). the compound of the present invention 94 [] 1H-NMR (CDCl3, TMS) δ (ppm): 7.34 (1H, d, J=8.5 Hz), 7.30 (1H, d, J=2.2 Hz) 6.98 (1H, dd, J=8.5 Hz, 2.2 Hz), 6.94 (1H, d, J=8.2 Hz), 6.70-6.72 (2H, m), 5.67 (1H, br.d, J=7.5 Hz), 5.00-5.04 (1H, m), 4.74 (2H, d, J=2.5 Hz), 3.81 (3H, s), 2.91 (2H, t, J=7.2 Hz), 2.47-2.50 (3H, m), 1.37 (3H, d, J=6.8 Hz) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In tetrahydrofuran; | (Process (c)) A mixture of 12.6 g (0.05 mol) of 4-amino-5-methylthio -2-phenoxycarbonyl-2,4-dihydro-3H-1,2,4-triazol-3-one, 9.5 g (0.05 mol) of 1-(3,4-dichlorophenyl) -ethylamine and 100 ml of tetrahydrofuran is stirred for 16 hours at 20 C. and subsequently concentrated. The residue is triturated with ethyl acetate, and the product obtained in the form of crystals is isolated by filtering off with suction. This gives 2.9 g (16% of theory) of 4-amino-5-methylthio -2-(1-(3,4-dichloro-phenyl)-ethylamino-carbonyl) -2,4-dihydro-3H-1,2,4-triazol-3-one of melting point 132 C. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In methanol; at 0 - 20℃; for 24h; | b/2.) 3 ' - { [ 1 -(3 ,4-Dichlorophenyl)ethyl] amino }propionitrile; To the solution of 1.1 g (5.8 mmol) [l-(3,4-dichlorophenyl)ethyl]arnine in 11 ml abs. methanol 0.4 ml (6 mmol) acrylonitrile is added under ice-water cooling, then the stirring is continued for 24 hours at room temperature. The solution is evaporated in vacuum to obtain 1.2 g title compound in the form of an oil. LC-MS[MH+]= 243 (C11H12Cl2N2 243.136). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20℃; for 5h; | To a solution of 143.8 mg (0.75 mmol) N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC.HCl) and 91.6 mg (0.75 mmol) 4-dimethylaminopyridine (DMAP) in 1.5 ml dichloromethane were added 142 mg (0.75 mmol) <strong>[74877-07-9]rac-1-(3,4-dichloro-phenyl)-ethylamine</strong> and the solution stirred at ambient temperature for 5 min. To this solution were added 70 mg (0.5 mmol) 3-fluoro-benzoic acid and the mixture stirred at ambient temperature for 5 hours.The reaction mixture was filtered through a cartridge filled with 2 g SCX/silica gel 1:1, pre-washed with 20 ml methanol and 20 ml dichloromethane, and the reaction product eluted with 20 ml dichloromethane. After evaporation rac-N-[1-(3,4-dichloro-phenyl)-ethyl]-3-fluoro-benzamide was obtained as colorless solid, MS (ISP): 311.9 and 314.0 ((M+H)+.). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In N,N-dimethyl-formamide; at 40℃;Inert atmosphere; | 5.60 l-[l-(3,4-Dichloro-phenyl)-ethyll-3-[2-(2,6-dioxo-piperidin-3-yl)-l-oxo- 2,3-dihydro-lH-isoindol-5-vlmethyll-urea; A stirred mixture of 3-(5-aminomethyl- 1 -oxo- 1 ,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione methane sulfonate (0.37 g, 1.00 mmol) and CDI (0.18 g, 1.10 mmol) in N,N- dimethylformamide (10 mL) was heated to 40 C under nitrogen overnight. l-(3,4-Dichloro-phenyl)- ethylamine (0.19 g, 1.00 mmol) was then added and the mixture was heated at 40 C overnight. Water (60 mL) was added, solid precipitated, was filtered, washed with water (30 mL) and was purified by preparative HPLC (gradient: CH3CN/H2O: 10/90 for 5 min, to 100/0 in 10 min, 100/0 for 5 min). Solvent was evaporated and the residue was triturated in ether (20 mL) for 1 h. The product was then isolated by filtration and dried in vacuo to give l-[l-(3,4-Dichloro-phenyl)-ethyl]-3-[2-(2,6-dioxo- piperidin-3-yl)-l-oxo-2,3-dihydro-lH-isoindol-5-ylmethyl]-urea as a white solid (0.084 g, 17% yield): HPLC: Waters Symmetry Ci8, 5μm, 3.9 x 150 mm, 1 mL/min, 240 nm, gradient: CH3CNA).1% H3PO4: 10/90 to 90/10 in 10 min, 90/10 (5 min): 8.57 min (96.68%); mp: 200-202 C; 1H NMR (DMSO-d6) δ 1.32 (d, J= 7.0 Hz, 3H, CH3), 1.88 - 2.13 (m, IH, CHH), 2.28 - 2.47 (m, IH, CHH), 2.55 - 2.70 (m, IH, CHH), 2.79 - 3.04 (m, IH, CHH), 4.18 - 4.55 (m, 4H, CH2, CH2), 4.74 (quin, J= 7.0 Hz, IH, CH), 5.11 (dd, J= 4.9, 13.2 Hz, IH, CH), 6.51 (s, IH, NH), 6.66 (d, J= 7.9 Hz, IH, NH), 7.20 - 7.46 (m, 3H, Ar), 7.48 - 7.62 (m, 2H, Ar), 7.65 (d, J= 7.7 Hz, IH, Ar), 10.99 (s, IH, NH); 13C NMR (DMSO-d6) δ 22.51, 22.80, 31.20, 42.86, 47.07, 48.18, 51.55, 121.61, 122.81, 126.28, 126.70, 127.78, 128.79, 130.14, 130.38, 130.77, 142.26, 145.29, 147.41, 157.20, 167.95, 170.98, 172.85; LCMS: MH = 489, 491; Anal Calcd for C23H22N4O4Cl2 + 0.9 H2O: C, 54.64, H, 4.75, N, 11.08; Found: C, 54.27, H, 4.66, N, 10.98. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In dimethyl sulfoxide; at 110℃; for 1.5h; | Examples 193 and 194A solution of (R)-3-(2-chloropyrimidin-4-yl)-4-phenyloxazolidin-2-one (83 mg, 0.30 mmol) and 1-(3,4-dichlorophenyl)ethanamine (260 mg, 1.37 mmol, 4.5 equiv) in DMSO (1.5 mL) was heated at 1 10 C for 1 ? h. The reaction mixture was diluted with EtOAc (8 mL) and washed with water (30 mL). After separation, the aqueous phase was extracted with EtOAc (3 x 8 mL). Combined organics were dried over Na2S04, filtered and concentrated. Silica gel column chromatography (EtO Ac/ Heptane 0 to 40%) provided (R)-3-(2-((/?)-1-(3,4-dichlorophenyl)ethylamino)pyrimidin-4-yl)-4-phenyloxazolidin-2-one and (R)-3-(2-((S)-1-(3,4-dichlorophenyl)ethylamino)pyrimidin-4-yl)-4-phenyloxazolidin-2- one.Example 193 first eluted product (13 mg) 1H NMR (400 MHz, CD3OD) ? 8.1 1 (d, J = 5.6 Hz, 1 H), 7.44 - 7.38 (m, 5 H), 7.35 - 7.31 (m, 1 H), 7.27 - 7.25 (m, 2 H), 7.18 (dd, J = 8.3, 2.3 Hz, 1 H), 5.53 (dd, J = 8.8, 3.8 Hz, 1 H), 4.76 (t, J = 8.8 Hz, 1 H), 4.59 - 4.53 (m, 1 H), 4.18 (dd, J = 8.8, 4.3 Hz, 1 H), 1.22 (d, J = 7.1 Hz, 3 H); HRMS(B) m/z 429.0899 (M + H)+.Example 194 second eluted product (26 mg) 1 H NMR (400 MHz, CD3OD) ? 8.13 (d, J = 5.6 Hz, 1 H), 7.41 (d, J = 6.1 Hz, 1 H), 7.25 - 7.18 (m, 5 H), 7.09 - 7.06 (m, 2 H), 6.95 - 6.93 (m, 1 H), 5.78 (dd, J = 8.6, 3.5 Hz, 1 H), 4.89 (q, J = 6.7 Hz, 1 H), 4.79 (t, J = 8.6 Hz, 1 H), 4.18 (dd, J = 8.8, 3.8 Hz, 1 H), 1 .42 (d. J = 7.1 Hz, 3 H); HRMS(B) m/z429.0887 (M + H)+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In dimethyl sulfoxide; at 110℃; for 1.5h; | Examples 177 and 178A solution of (S)-3-(2-chloropyrimidin-4-yl)-4-isopropyloxazolidin-2-one (93 mg, 0.38 mmol) and 1 -(3,4-dichlorophenyl)ethanamine (73.1 mg, 0.385 mmol, 1 .0 equiv) in DMSO (1 mL) was heated at 1 10 C for 1 ? h. The reaction mixture was diluted with EtOAc (8 mL) and washed with water (30 mL). After separation, the aqueous phase was extracted with EtOAc (3 x 8 mL). Combined organics were dried over Na2S04, filtered and concentrated. Silica gel column chromatography (EtOAc/Heptane 10 to 50%) provided (S)-3-(2-((/?)-1 -(3,4-dichlorophenyl)ethylamino)pyrimidin-4-yl)-4-isopropyloxazolidin-2- one and (S)-3-(2-((S)-1-(3,4-dichlorophenyl)ethylamino)pyrimidin-4-yl)-4- isopropyloxazolidin-2-one.Example 177 first eluted product (21 mg) 1H NMR (400 MHz, CD3OD) ? 8.12 (d, J = 5.8 Hz, 1 H), 7.50 (d, J = 2.0 Hz, 1 H), 7.44 (d, J = 8.2 Hz, 1 H), 7.37 (d, J = 5.8 Hz, 1 H), 7.28 (dd, J = 8.6, 2.0 Hz, 1 H), 4.94 - 4.88 (m, 1 H), 4.43 (br s, 1 H), 4.35 - 4.26 (m, 2 H), 2.68 - 2.60 (m, 1 H), 1 .50 (d, J = 7.1 Hz, 3 H), 0.99 (d, J = 7.1 Hz, 3 H), 0.85 (d, J = 7.1 Hz, 3 H); HRMS(B) m/z 395.1035 (M + H)+.Example 178 second eluted product (28 mg) 1H NMR (400 MHz, CD3OD) ? 8.15 (d, J = 5.8 Hz, 1 H), 7.47 - 7.42 (m, 2 H), 7.37 (d, J = 5.8 Hz, 1 H), 7.25 (dd, J = 8.1 , 2.0 Hz, 1 H), 5.01 - 4.96 (m, 1 H), 4.61 (br s, 1 H), 4.34 - 4.26 (m, 2 H), 1.72 (br s, 1 H), 1 .50 (d, J = 7.1 Hz, 3 H), 0.67 (br s, 3 H), 0.60 (br s, 3 H); HRMS(B) m/z 395.1044 (M + H)+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
General procedure: To a stirred solution of 2-chloro-4-oxo-4H-pyrido [1,2-a]pyrimidine-3-carbaldehyde (100mg, 0.479mmol) in THF (3mL) was added benzylamine (0.058mL, 0.527mmol) and TEA (0.1mL, 0.719mmol). The reaction mixture was stirred at 70C for 3h. after the mixture was concentrated, 1N aqueous HCl solution in THF (1/3 ratio, 4mL). The reaction mixture was stirred at 70C for 1h. after reaction was completed, the mixture was evaporated and neutralized to approximately pH 7 by adding 1N NaOH. The pale solid was collected by filtration and washed with H2O to give 5a (117mg, 87%) as a brown solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
0.005g; 0.006g | With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 120℃; for 1h;Microwave irradiation; | In a microwave vial charged with 1-(3,4-dichlorophenyl)ethanamine (0.25 g, 1.32 mmol, 1.0 eq.), (S)-3-(4-chloro-1,3,5-triazin-2-yl)-4-isopropyloxazolidin-2-one (0.32 g, 1.32 mmol, 1.0 eq.) and N,N-Diisopropylethylamine (0.71 mL, 3.96 mmol, 3.0 eq.), in isopropyl alcohol (5 mL). The resulting mixture was heated at 120 C. for 60 min. Following this, the reaction mixture was allowed to cool to RT concentrated under vacuum diluted with water (10 mL) and extracted using ethyl acetate (3×10 mL). The combined organic layers were washed with brine (10 mL), dried over anhydrous Na2SO4, filtered and evaporated under reduced pressure to get solid residue. The solid residue was purified by reverse phase column chromatography to get the title compounds. Compound 1.6 (0.005 g, 1%), UPLC-MS (Method 4): Rt 2.71, m/z 396.3 [M+1]+; 1H NMR (400 MHz, DMSO-d6) δ ppm 8.68 (d, J=7.89 Hz, 1H) 8.59 (d, J=7.89 Hz, 1H) 8.37 (s, 1H) 7.67 (d, J=1.75 Hz, 1H) 7.59 (dd, J=8.33, 2.19 Hz, 1H) 7.36 (d, J=8.33 Hz, 1H) 5.13-5.20 (m, 1H) 4.97-5.04 (m, 1H) 4.51-4.59 (m, 1H) 4.27-4.37 (m, 3H) 1.42-1.49 (m, 3H) 1.23 (s, 1H) 0.85-0.93 (m, 3H) 0.74-0.82 (m, 3H); and Compound 1.7 (0.006, 2% g). UPLC-MS (Method 4): Rt 2.69, m/z 396.3 [M+1]+; 1H NMR (400 MHz, DMSO-d6) δ ppm 8.71 (d, J=7.45 Hz, 1H) 8.37-8.42 (m, 1H) 7.54-7.66 (m, 2H) 7.28-7.39 (m, 2H) 5.12-5.20 (m, 1H) 5.00-5.10 (m, 1H) 4.57 (d, J=7.89 Hz, 1H) 4.45-4.51 (m, 1H) 4.22-4.36 (m, 3H) 1.44 (d, J=7.02 Hz, 3H) 1.23 (s, 1H) 0.88 (d, J=7.02 Hz, 1H) 0.72-0.79 (m, 3H) 0.62 (d, J=7.02 Hz, 2H) |
Tags: 74877-07-9 synthesis path| 74877-07-9 SDS| 74877-07-9 COA| 74877-07-9 purity| 74877-07-9 application| 74877-07-9 NMR| 74877-07-9 COA| 74877-07-9 structure
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P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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