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Chemical Structure| 284462-86-8 Chemical Structure| 284462-86-8

Structure of 284462-86-8

Chemical Structure| 284462-86-8

4-(4-Aminophenoxy)-N,N-dimethylpyridine-2-carboxamide

CAS No.: 284462-86-8

4.5 *For Research Use Only !

Cat. No.: A1012108 Purity: 95%

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Product Details of [ 284462-86-8 ]

CAS No. :284462-86-8
Formula : C14H15N3O2
M.W : 257.29
SMILES Code : O=C(C1=NC=CC(OC2=CC=C(N)C=C2)=C1)N(C)C
MDL No. :MFCD12678173
InChI Key :KFFKMBWNWNRVEB-UHFFFAOYSA-N
Pubchem ID :23614563

Safety of [ 284462-86-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 284462-86-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 284462-86-8 ]

[ 284462-86-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 114780-06-2 ]
  • [ 123-30-8 ]
  • [ 220000-87-3 ]
  • [ 284462-37-9 ]
  • [ 284462-86-8 ]
YieldReaction ConditionsOperation in experiment
70%; 69% [0137] A solution of 4-aminophenol (256 mg, 2.35 mmol) in dry N,Ndimethylformamide (40 mL) was treated with potassium tert-butoxide (274 mg, 2.44 mmol), and the reddish-brown mixture was stirred at room temperature for 1 hour. The contents were treated with 3a and 3b (400 mg, 2.35 mmol) and potassium carbonate (974 mg, 7.05 mmol) and then heated to 80 C under argon for 4 h. The mixture was cooled to room temperature and poured into ethyl acetate (100 mL) and brine (400 mL). The combined organics were washed with brine, dried over sodium sulfate, and concentrated. The crude reaction mixture was purified by column chromatography (dichloromethane/methanol) to afford the desired 4-(4-aminophenoxy)-N- methylpyridine-2-carboxamide 4a (400 mg, 1 .65 mmol, 70%) and 4-(4- aminophenoxy)-N,N-dimethylpyridine-2-carboxamide (69%) 4b after column as a light-brown solid.
 

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