GPR6 is a member of the G protein-coupled receptor family, characterized by seven transmembrane domains. It is primarily expressed in the central nervous system, especially in the cerebral cortex and striatum. GPR6 is involved in regulating neuronal activity and dopamine signaling, affecting motor control and cognitive function. Its specific expression and functional regulation are potentially crucial for the occurrence and treatment of neurodegenerative diseases. Mutations or aberrant expression of GPR6 are associated with the development of neurodegenerative disorders such as Parkinson's disease, schizophrenia, and cognitive impairment.